All Journals > The Journal of Infectious Diseases > 1 May 2008 > Mother‐to‐Child Transmission of CMV in Africa

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 May 2008

Volume 197, Number 9
The Journal of Infectious Diseases 2008;197:1307–1314
© 2008 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2008/19709-0013$15.00
DOI: 10.1086/586715
MAJOR ARTICLE

Virological and Immunological Correlates of Mother‐to‐Child Transmission of Cytomegalovirus in The Gambia

Steve Kaye,1

David Miles,1

Pierre Antoine,2

Wivine Burny,2

Bukky Ojuola,1

Pauline Kaye,1

Sarah Rowland‐Jones,1

Hilton Whittle,1

Marianne van der Sande,1 and

Arnaud Marchant1,2

1MRC Laboratories, Fajara, The Gambia; 2Institute for Medical Immunology, Charleroi, Belgium

Background.Cytomegalovirus (CMV) is the most common congenital infection and can follow primary and recurrent maternal infection. We studied correlates of vertical transmission of CMV in The Gambia, where most children acquire CMV during the first year of life.

Methods.A cohort of 281 mothers and infants was recruited at birth. Infants were prospectively followed up for CMV infection during the first year of life. Excretion of CMV and antiviral immune response were studied at birth in mothers of children infected in utero, early during infancy, or late during infancy or not infected at 1 year of age.

Results.Congenital infection was diagnosed in 3.9% of newborns, and 85% of children were infected by 1 year. Excretion of CMV in colostrum or in the genital tract was more common in mothers of congenitally (100%) or early infected children (48%) than in mothers of late‐infected (20%) or uninfected children (27%). Higher rates of viral excretion were associated with significantly higher levels of serum anti‐CMV immunoglobulin G and higher frequencies of CMV‐specific CD4+ T cells.

Conclusion.In the context of recurrent maternal infection, transmission of CMV in utero and during early postnatal life is associated with excretion of the virus in colostrum and the genital tract.

Received 27 July 2007; accepted 9 November 2007; electronically published 21 March 2008.

Reprints or correspondence: Dr. Arnaud Marchant, Institute for Medical Immunology, Rue Adrienne Bolland 8, 6041 Charleroi, Belgium ().

Cited by

Matthew Bates, Mwaka Monze, Humphrey Bima, Mirriam Kapambwe, David Clark, Francis C. Kasolo, Ursula A. Gompels. (2009) Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. Journal of Medical Virology 81:5, 779-789
Online publication date: 1-Jun-2009.
CrossRef
Jennifer A Slyker, Barbara L Lohman-Payne, Sarah L Rowland-Jones, Phelgona Otieno, Elizabeth Maleche-Obimbo, Barbra Richardson, Carey Farquhar, Dorothy Mbori-Ngacha, Vincent C Emery, Grace C John-Stewart. (2009) The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1-infected women and their infants. AIDS 23:1, 117-124
Online publication date: 1-Feb-2009.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: GlaxoSmithKline and the Medical Research Council, United Kingdom. A.M. is a senior research associate of the Fonds National de la Recherche Scientifique, Belgium.

Back to Top
Close Popup