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1 June 2008 Supplement

Volume 46, Number S5
Clinical Infectious Diseases 2008;46:S386–S393
© 2008 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4611S5-0008$15.00
DOI: 10.1086/533595
SUPPLEMENT ARTICLE

Management of Methicillin‐Resistant Staphylococcus aureus Bacteremia

Sara E. Cosgrove1 and

Vance G. Fowler, Jr.2

1Johns Hopkins University School of Medicine, Baltimore, Maryland; and 2Duke University Medical Center, Durham, North Carolina

Staphylococcus aureus bacteremia and endocarditis are serious infections that demand prompt clinical attention to ensure good outcomes. Of foremost importance is identifying and managing the source of infection and any associated complications. Evaluation for the presence of cardiac involvement is essential because inadequately managed S. aureus endocarditis is life threatening. Thus, physicians must aggressively negotiate treatment paths, considering whether the S. aureus bacteremia is complicated, whether foreign sources of infection should be removed or replaced, and whether surgical intervention is necessary. Selection of an antibiotic treatment is also an essential factor for optimal management. The increasing prevalence of methicillin‐resistant S. aureus (MRSA) infections has created a tremendous demand for effective and safe antimicrobial agents other than the historic anti‐MRSA agent vancomycin.

Reprints or correspondence: Dr. Sara E. Cosgrove, Johns Hopkins Medical Institutions, Osler 425, 600 N. Wolfe St., Baltimore, MD 21287 ().

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, O. Gallon, C. Guillet-Caruba, B. Lamy, F. Laurent, F. Doucet-Populaire, J.-W. Decousser. (2009) In vitro activity of daptomycin against Staphylococci isolated from bacteremia and community-onset skin and soft tissue infections in France: data from two nationwide studies. European Journal of Clinical Microbiology & Infectious Diseases
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Adolf W. Karchmer and Arnold S. Bayer. (2008) Introduction: Methicillin‐Resistant Staphylococcus aureus: An Evolving Clinical Challenge. Clinical Infectious Diseases 46:s5, S342-S343
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