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1 June 2008 Supplement

Volume 46, Number S5
Clinical Infectious Diseases 2008;46:S368–S377
© 2008 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4611S5-0006$15.00
DOI: 10.1086/533593
SUPPLEMENT ARTICLE

Skin and Soft‐Tissue Infections Caused by Community‐Acquired Methicillin‐Resistant Staphylococcus aureus

Martin E. Stryjewski1,2 and

Henry F. Chambers3

1Duke Clinical Research Institute, Durham, North Carolina; 2Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina; and 3Division of Infectious Diseases, University of California–San Francisco, San Francisco

Community‐acquired methicillin‐resistant Staphylococcus aureus (MRSA) infection has become epidemic. Skin and soft‐tissue infections (SSTIs) are the most frequent forms of the disease. Obtainment of culture specimens is important for documentation of the presence of MRSA and for susceptibility testing to guide therapy. Purulent lesions should be drained whenever possible. In areas where community‐acquired MRSA isolates are prevalent, uncomplicated SSTI in healthy individuals may be treated empirically with clindamycin, trimethoprim‐sulfamethoxazole, or long‐acting tetracyclines, although specific data supporting the efficacy of these treatments are lacking. In healthy patients with small purulent lesions, drainage alone may be sufficient. In patients with complicated SSTI requiring hospitalization or intravenous therapy, vancomycin is the drug of choice because of the low cost, efficacy, and safety. Linezolid, daptomycin, and tigecycline are also effective, although published studies on the last 2 agents for the treatment of SSTI due to MRSA are more limited. Dalbavancin, telavancin, and ceftobiprole are investigational agents that may expand our therapeutic options for the treatment of SSTI caused by MRSA.

Reprints or correspondence: Dr. Martin E. Stryjewski, Azcuenaga 1757, Apt. 1C, Capital Federal (C1128AAC), Buenos Aires, Argentina ().

Cited by

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Online publication date: 1-Aug-2009.
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Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis. (2009) Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States. Clinical Infectious Diseases 49:1, 65-71
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John D. Szumowski, Kenneth M. Wener, Howard S. Gold, Michael Wong, Lata Venkataraman, Carrie A. Runde, Daniel E. Cohen, Kenneth H. Mayer, and Sharon B. Wright. (2009) Methicillin‐Resistant Staphylococcus aureus Colonization, Behavioral Risk Factors, and Skin and Soft‐Tissue Infection at an Ambulatory Clinic Serving a Large Population of HIV‐Infected Men Who Have Sex with Men. Clinical Infectious Diseases 49:1, 118-121
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GEORGE Y. LIU. (2009) Molecular Pathogenesis of Staphylococcus aureus Infection. Pediatric Research 65:Supplement, 71R-77R
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Michael Otto. (2009) Looking toward basic science for potential drug discovery targets against community-associated MRSA. Medicinal Research Reviews n/a-n/a
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Helen W. Boucher, George H. Talbot, John S. Bradley, John E. Edwards, Jr, David Gilbert, Louis B. Rice, Michael Scheld, Brad Spellberg, and John Bartlett. (2009) Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America. Clinical Infectious Diseases 48:1, 1-12
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Blanca E. Gonzalez, Sheldon L. Kaplan. (2008) Severe Staphylococcal Infections in Children. Pediatric Annals 37:10, 686-693
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Lena M. Napolitano. (2008) Early Appropriate Parenteral Antimicrobial Treatment of Complicated Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. Surgical Infections 9:s1, s17-s27
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Adolf W. Karchmer and Arnold S. Bayer. (2008) Introduction: Methicillin‐Resistant Staphylococcus aureus: An Evolving Clinical Challenge. Clinical Infectious Diseases 46:s5, S342-S343
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