All Journals > The Journal of Infectious Diseases > 15 April 2008 > Vaccine against Clades 1 and 2 H5N1 Viruses

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

15 April 2008

Volume 197, Number 8
The Journal of Infectious Diseases 2008;197:1185–1188
© 2008 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2008/19708-0015$15.00
DOI: 10.1086/529522
BRIEF REPORT

A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses

Mary A. Hoelscher,1,a

Neetu Singh,2,a

Sanjay Garg,1

Lakshmi Jayashankar,2

Vic Veguilla,1

Aseem Pandey,2

Yumi Matsuoka,1

Jacqueline M. Katz,1

Ruben Donis,1

Suresh K. Mittal,2 and

Suryaprakash Sambhara1

1Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; and 2Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana

Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg‐derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg‐independent vaccines. We developed an adenoviral vector–based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.

Received 27 September 2007; accepted 31 October 2007; electronically published 18 March 2008.

Reprints or correspondence: Dr. Suryaprakash Sambhara, Influenza Div., Centers for Disease Control and Prevention, 1600 Clifton Rd., Mail stop G16, Atlanta, GA 30333 (); or Dr. Suresh K. Mittal, Dept. of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 ().

Cited by

Marcio O Lasaro, Hildegund CJ Ertl. (2009) New Insights on Adenovirus as Vaccine Vectors. Molecular Therapy
Online publication date: 9-Jul-2009.
CrossRef
Hala Ibrahim Awadalla, Nagwa F. El-Kholy, Ahmed B. Barakat. (2009) Trends of influenza infection in Egypt during two consecutive seasons. Journal of Public Health 17:3, 195-203
Online publication date: 1-Jul-2009.
CrossRef
Mary Hoelscher, Shivaprakash Gangappa, Weimin Zhong, Lakshmi Jayashankar, Suryaprakash Sambhara. (2008) Vaccines against epidemic and pandemic influenza. Expert Opinion on Drug Delivery 5:10, 1139-1157
Online publication date: 1-Nov-2008.
CrossRef
M.-W. Chen, T.-J. R. Cheng, Y. Huang, J.-T. Jan, S.-H. Ma, A. L. Yu, C.-H. Wong, D. D. Ho. (2008) A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses. Proceedings of the National Academy of Sciences 105:36, 13538-13543
Online publication date: 9-Oct-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Work at Purdue University was supported by the National Institute of Allergy and Infectious Diseases (grant AI059374), and work at the Centers for Disease Control and Prevention (CDC) was funded by the CDC's National Center for Infectious Diseases and National Vaccine Program Office.

    The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the funding agencies.

  • M.A.H. and N.S. contributed equally to this article.

Back to Top
Close Popup