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15 March 2008

Volume 197, Number 6
The Journal of Infectious Diseases 2008;197:803–811
© 2008 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2008/19706-0005$15.00
DOI: 10.1086/528804
MAJOR ARTICLE

Phenotypic Changes in Influenza‐Specific CD8+ T Cells after Immunization of Children and Adults with Influenza Vaccines

Xiao‐Song He,1,5

Tyson H. Holmes,2

Kutubuddin Mahmood,6,a

George W. Kemble,6

Cornelia L. Dekker,3

Ann M. Arvin,3,4,b and

Harry B. Greenberg1,4,5,b

Departments of 1Medicine, 2Health Research and Policy (Biostatistics), 3Pediatrics, and 4Microbiology and Immunology, Stanford University School of Medicine, Stanford, 5VA Palo Alto Health Care System, Palo Alto, and 6Medimmune Vaccines, Mountain View, California

The effect of trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV) on the phenotypes of circulating influenza‐specific CD8+ T cells was analyzed by interferon (IFN)–γ flow cytometry and tetramer staining. In adults, the expression of the T cell differentiation marker CD27 on virus‐specific CD8+ T cells decreased after LAIV but increased after TIV. In children, expression of the cytotoxicity molecule perforin in influenza‐specific CD8+ T cells increased after TIV but not after LAIV. Among children aged 6 months to 4 years who had not been vaccinated previously and who received 2 doses of TIV, CD27 expression decreased after each dose, whereas perforin expression increased after the second dose. These findings indicate that the phenotypic changes of influenza‐specific CD8+ T cells differ depending on the type of vaccine and the age of the vaccinee. These differences are potentially affected by the different routes of vaccination and pathways of antigen presentation for TIV and LAIV.

Received 26 June 2007; accepted 19 October 2007; electronically published 14 February 2008.

Reprints or correspondence: Dr. Xiao‐Song He, VA Palo Alto Health Care System 154C, 3801 Miranda Ave., Palo Alto, CA 94304 ().

Cited by

C. I. Yu, M. Gallegos, F. Marches, G. Zurawski, O. Ramilo, A. Garcia-Sastre, J. Banchereau, A. K. Palucka. (2008) Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines. Blood 112:9, 3671-3678
Online publication date: 1-Dec-2008.
CrossRef

  • Potential conflicts of interest: A.M.A. and H.B.G. are paid consultants to Medimmune Vaccines, the manufacturer of the live attenuated influenza vaccine used in this study.

    Presented in part: 26th Annual Meeting of American Society for Virology, Corvallis, Oregon, 14–18 July 2007 (abstract W38–6).

    Financial support: National Institutes of Health (grants AI057229, DK56339, and 5M01RR000070).

  • Present affiliation: Novavax, Inc., Rockville, Maryland.

  • A.M.A. and H.B.G. contributed equally to this work.

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