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1 March 2008

Volume 197, Number 5
The Journal of Infectious Diseases 2008;197:663–666
© 2008 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2008/19705-0008$15.00
DOI: 10.1086/527330
BRIEF REPORT

Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by Real‐Time Reverse-Transcriptase Polymerase Chain Reaction Assay in Chronic Active Epstein‐Barr Virus Infection

Yoshinori Ito,1

Yukiko Shibata‐Watanabe,1

Yoko Ushijima,2

Jun‐ichi Kawada,1

Yukihiro Nishiyama,2

Seiji Kojima,1 and

Hiroshi Kimura2

1 Department of Pediatrics and 2 Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Chronic active Epstein‐Barr virus infection (CAEBV) is characterized by recurrent infectious mononucleosis–like symptoms and has high mortality and morbidity. To clarify the mechanisms of CAEBV, the gene‐expression profiles of peripheral blood obtained from patients with CAEBV were investigated. Twenty genes were differentially expressed in 4 patients with CAEBV. This microarray result was verified using a real‐time reverse-transcriptase polymerase chain reaction assay in a larger group of patients with CAEBV. Eventually, 3 genes were found to be significantly upregulated: guanylate binding protein 1, tumor necrosis factor–induced protein 6, and guanylate binding protein 5. These genes may be associated with the inflammatory reaction or with cell proliferation.

Received 19 June 2007; accepted 24 September 2007; electronically published 8 February 2008.

Reprints or correspondence: Hiroshi Kimura, MD, PhD, Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai‐cho, Showa‐ku, Nagoya 466–8550, Japan ().

Cited by

Jeffrey I. Cohen. (2008) Optimal treatment for chronic active Epstein-Barr virus disease. Pediatric Transplantation
Online publication date: 1-Dec-2008.
CrossRef

  • Presented in part: 32nd International Herpesvirus Workshop, Asheville, North Carolina, 7–12 July 2007 (abstract 3.13).

    Potential conflicts of interest: none reported.

    Financial support: Japan Society for the Promotion of Science (Grant‐in‐Aid for Scientific Research [C] [18591212] to Y.I.).

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