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15 February 2008

Volume 197, Number 4
The Journal of Infectious Diseases 2008;197:593–596
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2008/19704-0015$15.00
DOI: 10.1086/526499
BRIEF REPORT

Human Cytomegalovirus (HCMV) DNAemia in the Mother at Amniocentesis as a Risk Factor for Iatrogenic HCMV Infection of the Fetus

Maria Grazia Revello, 1

Milena Furione,1

Maurizio Zavattoni,1

Beatrice Tassis,2

Umberto Nicolini,2

Elisa Fabbri,2 and

Giuseppe Gerna1

1Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, and 2Dipartimento di Ostetricia e Ginecologia, Ospedale V. Buzzi, Università di Milano, Milano, Italy

To investigate whether invasive procedures performed in the presence of human cytomegalovirus (HCMV) DNA in maternal peripheral blood (HCMV DNAemia) represent a risk for iatrogenic transmission of HCMV infection to the fetus, 194 pregnant women undergoing prenatal diagnosis because of a primary HCMV infection and their 199 fetuses were investigated. Overall, 27 (37%) of 73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia‐positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false‐negative amniocentesis results, 4 were DNAemia‐positive and 4 were DNAemia‐negative at amniocentesis. Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis.

Received 19 July 2007; accepted 6 September 2007; electronically published 1 February 2008.

Reprints or correspondence: Dr. Maria Grazia Revello, Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia ().

Cited by

Maria Grazia Revello, Giuseppe Gerna. (2008) Maternal, fetal and neonatal diagnosis of congenital human cytomegalovirus infection. Expert Opinion on Medical Diagnostics 2:5, 547-563
Online publication date: 1-Jun-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Ministero della Salute, Fondazione IRCCS Policlinico San Matteo, Ricerca Corrente (grant 80513), and Ricerca Finalizzata 2006, and Fondazione Cariplo (grant 93005).

    Presented in part: 11th CMV Workshop, Toulouse, France, May 2007 (abstract S3‐P20).

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