All Journals > Clinical Infectious Diseases > 1 February 2008 > HHV‐6 Infection in the Gastroduodenal Mucosa

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 February 2008

Volume 46, Number 3
Clinical Infectious Diseases 2008;46:434–439
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4603-0012$15.00
DOI: 10.1086/525264
MAJOR ARTICLE

Human Herpesvirus 6 Infection of the Gastroduodenal Mucosa

Leena Halme,1

Johanna Arola,2

Krister Höckerstedt,1 and

Irmeli Lautenschlager1,3

Department of 1Transplantation and Liver Surgery, Transplant Unit Research Laboratory, Helsinki University Hospital, and Departments of 2Pathology and 3Virology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland

Background.Human herpesvirus 6 (HHV‐6) infections are usually asymptomatic reactivations in adult liver transplant recipients, but they may also cause fever or graft dysfunction. HHV‐6 infection can also present symptoms of gastroenteritis. In this study, we investigated the presence of HHV‐6 in the gastroduodenal mucosa of liver transplant recipients and in immunocompetent patients undergoing gastroscopic examination because of dyspeptic symptoms.

Methods.HHV‐6 and cytomegalovirus (CMV) examinations were performed on gastroduodenal biopsy specimens obtained during upper gastrointestinal endoscopic examinations from 90 liver transplant recipients and from 31 immunocompetent patients with upper gastrointestinal symptoms. In the gastroduodenal mucosa, HHV‐6 and CMV was demonstrated by immunohistochemistry in frozen sections using monoclonal antibodies against HHV‐6– and CMV‐specific antigens.

Results.HHV‐6–positive cells were found in biopsy specimens from 21 (23%) of the liver transplant recipients and 6 (19%) of the immunocompetent patients, CMV‐positive cells were found in specimens from 55 (61%) of the transplant recipients and 7 (23%) of the immunocompetent patients, and 12 transplant recipients were found to have both HHV‐6 and CMV infection. Fifteen transplant recipients with positive HHV‐6 findings in the gastroduodenal mucosa also had HHV‐6 antigenemia, whereas 30 patients with HHV‐6 antigenemia did not have gastroduodenal involvement. Endoscopic findings in these patients included biliary complications in 10 patients and gastritis in 2 patients. Histopathological findings were nonspecific and included very mild inflammation. A total of 30 (94%) of the transplant recipients with biliary complications also had HHV‐6 or CMV detected in the duodenal mucosa.

Conclusions.HHV‐6–positive cells and CMV‐positive cells were frequently found in the gastroduodenal mucosa of liver transplant recipients and of immunocompetent patients undergoing gastroscopic examination because of dyspeptic symptoms.

Received 22 June 2007; accepted 28 September 2007; electronically published 21 December 2007.

Reprints or correspondence: Dr. Leena Halme, Dept. of Transplantation and Liver Surgery, Helsinki University Hospital, Box 263, FIN‐00029 Helsinki, Finland ().

Cited by

L. Potenza, P. Barozzi, M. Masetti, M. Pecorari, P. Bresciani, A. Gautheret-Dejean, G. Riva, D. Vallerini, S. Tagliazucchi, M. Codeluppi, F. Di Benedetto, G. E. Gerunda, F. Narni, G. Torelli, M. Luppi. (2009) Prevalence of Human Herpesvirus-6 Chromosomal Integration (CIHHV-6) in Italian Solid Organ and Allogeneic Stem Cell Transplant Patients. American Journal of Transplantation 9:7, 1690-1697
Online publication date: 1-Aug-2009.
CrossRef
Masao Ogata, Jun-ichi Kadota. (2008) Human herpesvirus-6 infections and infection-preventative measures in transplant recipients. Future Virology 3:6, 567-578
Online publication date: 1-Dec-2008.
CrossRef
F. Lamoth, P.Y. Jayet, J.D. Aubert, S. Rotman, C. Mottet, R. Sahli, I. Lautenschlager, M. Pascual, P. Meylan. (2008) Case Report: Human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient. Journal of Medical Virology 80:10, 1804-1807
Online publication date: 1-Nov-2008.
CrossRef
Back to Top
Close Popup