Early Sequential Development of Infective Dermatitis, Human T Cell Lymphotropic Virus Type 1–Associated Myelopathy, and Adult T Cell Leukemia/Lymphoma
1Laboratory of Immunoregulation and Microbiology, Centro de Pesquisa Conçalo Moniz–Fundação Oswaldo Cruz, and Departments of 2Internal Medicine and 3Pathology, Hospital Universitário Prof. Edgard Santos, Federal University of Bahia, Bahia, Brazil; and 4Clinical and Epidemiological Virology, Rega Institute, Katholieke Universiteit, Leuven, Belgium
We describe a patient with human T cell lymphotropic virus type 1 (HTLV‐1)–associated infective dermatitis who developed HTLV‐1–associated myelopathy/tropical spastic paraparesis and adult T cell leukemia/lymphoma at 16 years of age. Long inverse polymerase chain reaction was used to demonstrate monoclonal integration of proviral DNA in the lymphomatous skin lesion.
Received 24 July 2007; accepted 23 August 2007; electronically published 3 January 2008.
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Online publication date: 1-Aug-2009.
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