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1 February 2008 Supplement

Volume 46, Number S2
Clinical Infectious Diseases 2008;46:S96–S100
1058-4838/2008/4603S2-0010$15.00
DOI: 10.1086/523333
SUPPLEMENT ARTICLE

Clinical Indications for Probiotics: An Overview

B. R. Goldin and

S. L. Gorbach

Tufts University School of Medicine, Boston, Massachusetts

Probiotic bacteria are used to treat or prevent a broad range of human diseases, conditions, and syndromes. In addition, there are areas of medical use that have been proposed for future probiotic applications. Randomized double‐blind studies have provided evidence of probiotic effectiveness for the treatment and prevention of acute diarrhea and antibiotic‐induced diarrhea, as well as for the prevention of cow milk–induced food allergy in infants and young children. Research studies have also provided evidence of effectiveness for the prevention of traveler’s diarrhea, relapsing Clostridium difficile–induced colitis, and urinary tract infections. There are also studies indicating that probiotics may be useful for prevention of respiratory infections in children, dental caries, irritable bowel syndrome, and inflammatory bowel disease. Areas of future interest for the application of probiotics include colon and bladder cancers, diabetes, and rheumatoid arthritis. The probiotics with the greatest number of proven benefits are Lactobacillus rhamnosus strain GG and Saccharomyces boulardii.

Reprints or correspondence: Dr. Barry R. Goldin, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111 ().

Cited by

John G. Bartlett. (2009) New antimicrobial agents for patients with Clostridium difficile infections. Current Infectious Disease Reports 11:1, 21-28
Online publication date: 1-Feb-2009.
CrossRef
DAVID CA CANDY, SARA J HEATH, JONATHAN DN LEWIS, LINDA V THOMAS. (2008) Probiotics for the young and the not so young. International Journal of Dairy Technology 61:3, 215-221
Online publication date: 1-Sep-2008.
CrossRef
Carmen Tamayo. (2008) Clinical Research on Probiotics: The Interface between Science and Regulation. Clinical Infectious Diseases 46:s2, S101-S103
Online publication date: 1-Feb-2008.
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