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15 November 2007

Volume 45, Number 10
Clinical Infectious Diseases 2007;45:e128–e130
1058-4838/2007/4510-00E2$15.00
DOI: 10.1086/522764
BRIEF REPORT

Psychosis in a 12‐Year‐Old HIV‐Positive Girl with an Increased Serum Concentration of Efavirenz

Elizabeth A. Lowenhaupt,1,2

Kelly Matson,3

Bushra Qureishi,1

Akihiko Saitoh,5 and

David Pugatch2,4

Departments of 1Psychiatry and Human Behavior and 2Pediatrics, Brown Medical School, 3Department of Pharmacy Practice, University of Rhode Island College of Pharmacy, and 4Division of Pediatric Infectious Diseases, Rhode Island Hospital, Providence, Rhode Island, and 5Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California

Clearance and adverse effects of efavirenz are associated with CYP2B6‐G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12‐year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6‐G516T.

Received 15 April 2007; accepted 2 August 2007; electronically published 5 October 2007.

Reprints or correspondence: Dr. Elizabeth A. Lowenhaupt, Emma Pendleton Bradley Hospital, 1011 Veterans’ Memorial Pkwy., Riverside, RI 02915 ().

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