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15 November 2007

Volume 45, Number 10
Clinical Infectious Diseases 2007;45:1290–1295
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4510-0006$15.00
DOI: 10.1086/522537
MAJOR ARTICLE

Impact of Extensive Drug Resistance on Treatment Outcomes in Non–HIV‐Infected Patients with Multidrug‐Resistant Tuberculosis

Hye‐Ryoun Kim,1

Seung Sik Hwang,2

Hyun Ji Kim,1

Sang Min Lee,1

Chul‐Gyu Yoo,1

Young Whan Kim,1

Sung Koo Han,1

Young‐Soo Shim,1 and

Jae‐Joon Yim1

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, and 2Division of Chronic Disease Surveillance, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea

Background.Recently, serious concerns about extensively drug‐resistant tuberculosis (XDR‐TB), which shows resistance to second‐line anti‐TB drugs in addition to isoniazid and rifampicin, have been raised. The aim of this study was to elucidate the impact of extensive drug resistance on treatment outcomes in non–human immunodeficiency virus (HIV)–infected patients with multidrug‐resistant tuberculosis (MDR‐TB).

Methods.Patients who received the diagnosis of and treatment as having MDR‐TB at Seoul National University Hospital (Seoul, Republic of Korea) between January 1996 and December 2005 were included. The definition of XDR‐TB was TB caused by bacilli showing resistance to both isoniazid and rifampicin and also showing resistance to any fluoroquinolone and to at least 1 of the following 3 injectable anti‐TB drugs: capreomycin, kanamycin, and amikacin. To identify the impact of extensive drug resistance on treatment outcomes, univariate comparison and multiple logistic regression were performed.

Results.A total of 211 non–HIV–infected patients with MDR‐TB were included in the final analysis. Among them, 43 patients (20.4%) had XDR‐TB. Treatment failure was observed in 19 patients (44.2%) with XDR‐TB, whereas treatment of 46 patients (27.4%) with non–XDR‐TB failed ( ). The presence of extensive drug resistance (adjusted odds ratio [OR], 4.46; 95% confidence interval [CI], 1.35–14.74) and underlying comorbidity (adjusted OR, 2.62; 95% CI, 1.00–6.87) were independent risk factors for treatment failure. However, a higher level of albumin was inversely associated with treatment failure (adjusted OR, 0.87; 95% CI, 0.77–0.97).

Conclusion.The presence of extensive drug resistance, the presence of comorbidity, and hypoalbuminemia were independent poor prognostic factors in non–HIV‐infected patients with MDR‐TB.

Received 26 February 2007; accepted 2 August 2007; electronically published 15 October 2007.

Reprints or correspondence: Dr. Jae‐Joon Yim, Div. of Pulmonary and Critical Care Medicine, Dept. of Internal Medicine, Seoul National University Hospital, 28 Yongon‐dong, Chongno‐gu, Seoul 110‐744, South Korea ().

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