All Journals > The Journal of Infectious Diseases > 1 December 2007 > H5N1 Avian Influenza in Thailand

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 December 2007

Volume 196, Number 11
The Journal of Infectious Diseases 2007;196:1679–1684
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19611-0016$15.00
DOI: 10.1086/522007
MAJOR ARTICLE

Transmission of the Highly Pathogenic Avian Influenza Virus H5N1 within Flocks during the 2004 Epidemic in Thailand

Thanawat Tiensin,1,5

Mirjam Nielen,5

Hans Vernooij,5

Thaweesak Songserm,4

Wantanee Kalpravidh,2

Sirikan Chotiprasatintara,1

Arunee Chaisingh,3

Surapong Wongkasemjit,3

Karoon Chanachai,1

Weerapong Thanapongtham,1

Thinnarat Srisuvan,3 and

Arjan Stegeman5

1Department of Livestock Development, Ministry of Agriculture and Cooperatives, 2Food and Agriculture Organization of the United Nations, Regional Office for Asia and the Pacific, 3National Institute of Animal Health, Bangkok, and 4Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand; 5Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

This present study is the first to quantify the transmission of avian influenza virus H5N1 within flocks during the 2004 epidemic in Thailand. It uses the flock‐level mortality data to estimate the transmission‐rate parameter (β) and the basic reproduction number (R0). The point estimates of β varied from 2.26/day (95% confidence interval [CI], 2.01–2.55) for a 1‐day infectious period to 0.66/day (95% CI, 0.50–0.87) for a 4‐day infectious period, whereas the accompanying R0 varied from 2.26 (95% CI, 2.01–2.55) to 2.64 (95% CI, 2.02–3.47). Although the point estimates of β of backyard chickens and fighting cocks raised together were lower than those of laying hens and broiler chickens, this difference was not statistically significant. These results will enable us to assess the control measures in simulation studies. They also indicate that, for the elimination of the virus, a critical proportion of the susceptible poultry population in a flock (i.e., 80% of the population) needs to be vaccinated.

Received 19 December 2006; accepted 9 February 2007; electronically published 25 October 2007.

Reprints or correspondence: Thanawat Tiensin, Dept. of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands (, ).

Global Theme Issue: Poverty and Human Development

Cited by

M. LESNOFF, M. PEYRE, P. C. DUARTE, J.-F. RENARD, J. C. MARINER. (2009) A simple model for simulating immunity rate dynamics in a tropical free-range poultry population after avian influenza vaccination. Epidemiology and Infection 1
Online publication date: 30-Apr-2009.
CrossRef
M. P. WARD, D. MAFTEI, C. APOSTU, A. SURU. (2009) Estimation of the basic reproductive number ( R0) for epidemic, highly pathogenic avian influenza subtype H5N1 spread. Epidemiology and Infection 137:02, 219
Online publication date: 1-Mar-2009.
CrossRef
Y-X. Hao, J-M. Yang, C. He, Q. Liu, Tim A. McAllister. (2008) Reduced Serologic Response to Avian Influenza Vaccine in Specific-Pathogen-Free Chicks Inoculated with Cryptosporidium baileyi. Avian Diseases 52:4, 690
Online publication date: 1-Feb-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Royal Government of Thailand (scholarship to T.T.); Thai Department of Livestock Development, Ministry of Agriculture and Cooperatives (support to T.T.).

Back to Top
Close Popup