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15 October 2007

Volume 45, Number 8
Clinical Infectious Diseases 2007;45:1008–1013
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4508-0011$15.00
DOI: 10.1086/521896
REVIEW ARTICLE

Leukocyte Reduction's Role in the Attenuation of Infection Risks among Transfusion Recipients

Joseph S. Cervia,1,2

Barry Wenz,1 and

Girolamo A. Ortolano1

1Pall Medical, East Hills, and 2Albert Einstein College of Medicine, Bronx, New York

Despite advances in the screening of donated blood for infectious agents, the risk of transmitting viral, bacterial, and protozoal infections, as well as newly emerging diseases, via transfusion persists. A complementary approach is leukocyte reduction (LR), the removal of leukocytes from donated blood by filtration. Published evidence, establishing the benefit of LR in reducing the risk of febrile nonhemolytic reactions, cytomegalovirus transmission, and human leukocyte antigen alloimmunization has led to its use for some time for the care of immunosuppressed and other individuals considered to be at high risk for such complications. Recent literature suggests that LR may be effective in reducing the risk of transmission of a number of additional transfusion‐transmitted infectious agents, including herpesviruses, retroviruses, bacteria, protozoa, and prions. There is also evidence that LR may reduce the risk of transfusion‐related immunomodulation, further contributing to protection against infections that would complicate treatment. With the mounting evidence of potential benefit, a number of countries, as well as many hospitals and blood centers in the United States, have adopted a policy of performing LR for all donated blood. Physicians who care for immunosuppressed patients and those who are responsible for institutional infection‐control practices should remain informed of the growing body of literature on LR.

Received 5 April 2007; accepted 4 June 2007; electronically published 6 September 2007.

Reprints or correspondence: Dr. Joseph S. Cervia, Pall Medical, 2200 Northern Blvd., East Hills, NY 11548 ().

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Neil Blumberg and Joanna M. Heal. (2007) Editorial Commentary: Universal Leukocyte Reduction of Blood Transfusions. Clinical Infectious Diseases 45:8, 1014-1015
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