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1 October 2007

Volume 196, Number 7
The Journal of Infectious Diseases 2007;196:1102–1107
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19607-0024$15.00
DOI: 10.1086/521307
BRIEF REPORT

The Association between Trichomonas vaginalis Infection and Level of Vaginal Lactobacilli, in Nonpregnant Women

Michelle R. Torok,1

William C. Miller,1

Marcia M. Hobbs,2

Pia D. M. MacDonald,3,4

Peter A. Leone,2

Jane R. Schwebke,5 and

Arlene C. Seña2

1Department of Epidemiology, School of Public Health, 2Division of Infectious Diseases, Department of Medicine, 3North Carolina Center for Public Health Preparedness, and 4North Carolina Institute for Public Health, University of North Carolina at Chapel Hill, Chapel Hill; 5Department of Medicine, University of Alabama at Birmingham, Birmingham

The effect that vaginal lactobacilli have on trichomoniasis is not known. At 3 clinics for treatment of sexually transmitted disease, we recruited 521 female patients with trichomoniasis and 176 control subjects. All participants underwent physical examinations and testing for sexually transmitted infection and completed questionnaires. Low levels of vaginal lactobacilli were associated with trichomoniasis (odds ratio [OR], 2.2 [95% confidence interval {CI}, 1.4–3.2]). After adjustment for covariables, this association remained in women with a higher educational level (OR, 4.6 [95% CI, 2.2–9.5]) but not in women with a lower educational level (OR, 1.6 [95% CI, 0.7–3.4]). Vaginal lactobacilli may be associated with trichomoniasis in women with higher levels of education or a related behavioral factor.

Received 12 January 2007; accepted 29 April 2007; electronically published 23 August 2007.

Reprints or correspondence: Michelle Torok, Dept. of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 2106B McGavran‐Greenberg, CB #7435, Chapel Hill, NC 27599 ().

Cited by

Thomas A. Peterman, Lin H. Tian, Carol A. Metcalf, C. Kevin Malotte, Sindy M. Paul, John M. Douglas Jr, for the RESPECT‐2 Study Group. (2009) Persistent, Undetected Trichomonas vaginalis Infections?. Clinical Infectious Diseases 48:2, 259-260
Online publication date: 15-Jan-2009.
Citation-Full Text-PDF Version (155 kB)

  • Potential conflicts of interest: none reported.

    Financial support: National Institutes of Health STD Clinical Trials Unit (grant N01AI075329); North Carolina STI/TM Cooperative Research Center (grant U19AI031496).

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