All Journals > The Journal of Infectious Diseases > 15 September 2007 > Association between HPV and Sun‐Exposed Skin

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

15 September 2007

Volume 196, Number 6
The Journal of Infectious Diseases 2007;196:876–883
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19606-0011$15.00
DOI: 10.1086/521031
MAJOR ARTICLE

Cutaneous Human Papillomaviruses Found in Sun‐Exposed Skin: Beta‐papillomavirus Species 2 Predominates in Squamous Cell Carcinoma

Ola Forslund,1

Thomas Iftner,6

Kristin Andersson,1

Bernt Lindelöf,3

Eva Hradil,2

Peter Nordin,4

Bo Stenquist,5

Reinhard Kirnbauer,8

Joakim Dillner,1 and

Ethel‐Michele de Villiers,4 for the

Viraskin Study Groupa

1Department of Medical Microbiology, Malmö University Hospital, Lund University, and 2Department of Dermatology, Malmö University Hospital, Malmö, 3Department of Dermatology, Karolinska University Hospital, Stockholm, and 4Dermatology Clinic, Läkarhuset, and 5Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden; 6Medical Virology, Section of Experimental Virology, University Hospital of Tübingen, and 7Division of Tumourvirus Characterization, Deutsches Krebsforschungszentrum Heidelberg, Germany; 8Laboratory of Viral Oncology, Division of Immunology, Allergy and Infectious Diseases, Medical University Vienna, Austria

Background.A spectrum of cutaneous human papillomaviruses (HPVs) is detectable in nonmelanoma skin cancers, as well as in healthy skin, but the significance that the presence of these types of HPV DNA has for the pathogenesis of skin cancer remains unclear.

Methods.We studied 349 nonimmunosuppressed patients with skin lesions (82 with squamous cell carcinomas, 126 with basal cell carcinomas, 49 with actinic keratoses, and 92 with benign lesions). After superficial skin had been removed by tape, paired biopsy samples—from the lesion and from healthy skin from the same patient—were tested for HPV DNA. Risk factors for HPV DNA were analyzed in multivariate models.

Results.Overall, 12% of healthy skin samples were positive for HPV DNA, compared with 26% of benign lesions, 22% of actinic keratoses, 18% of basal cell carcinomas, and 26% of squamous cell carcinomas. HPV DNA was associated with sites extensively exposed to the sun, both for the lesions (odds ratio [OR], 4.45 [95% confidence interval {CI}, 2.44–8.11]) and for the healthy skin samples (OR, 3.65 [95% CI 1.79–7.44]). HPV types of Beta‐papillomavirus species 2 predominate in squamous cell carcinomas (OR, 4.40 [95% CI, 1.92–10.06]), whereas HPV types of Beta‐papillomavirus species 1 are primarily found in benign lesions (OR, 3.47 [95% CI, 1.72–6.99]).

Conclusions.Cutaneous HPV types are primarily detected at sites extensively exposed to the sun. HPV types of Beta‐papillomavirus species 2, but not of species 1, are associated with squamous cell carcinoma.

Received 1 February 2007; accepted 3 April 2007; electronically published 6 August 2007.

Reprints or correspondence: Ola Forslund, Medical Microbiology, Entrance 78, UMAS, SE‐20502 Malmö, Sweden ().

Cited by

T. Waterboer, R. Neale, K. M. Michael, P. Sehr, M. N. C. de Koning, S. J. Weissenborn, F. Sampogna, D. Abeni, A. C. Green, J. N. Bouwes Bavinck, M. Pawlita, . (2009) Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia. Journal of General Virology 90:8, 1986-1998
Online publication date: 1-Sep-2009.
CrossRef
E.-M. de Villiers, K. Gunst. (2009) Characterization of seven novel human papillomavirus types isolated from cutaneous tissue, but also present in mucosal lesions. Journal of General Virology 90:8, 1999-2004
Online publication date: 1-Sep-2009.
CrossRef
M. N. C. de Koning, S. J. Weissenborn, D. Abeni, J. N. Bouwes Bavinck, S. Euvrard, A. C. Green, C. A. Harwood, L. Naldi, R. Neale, I. Nindl, C. M. Proby, W. G. V. Quint, F. Sampogna, J. ter Schegget, L. Struijk, U. Wieland, H. J. Pfister, M. C. W. Feltkamp, . (2009) Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. Journal of General Virology 90:7, 1611-1621
Online publication date: 1-Aug-2009.
CrossRef
Natasa Vasiljević, Kristin Andersson, Kaj Bjelkenkrantz, Christer Kjellström, Henrik Månsson, Elise Nilsson, Goran Landberg, Joakim Dillner, Ola Forslund. (2009) The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma. International Journal of Cancer 124:10, 2361-2366
Online publication date: 15-Jun-2009.
CrossRef
Jean Baptiste Ruer, Line Pépin, Tarik Gheit, Chrystelle Vidal, Bernadette Kantelip, Massimo Tommasino, Jean Luc Prétet, Christiane Mougin, François Aubin. (2009) Detection of alpha- and beta-human papillomavirus (HPV) in cutaneous melanoma: a matched and controlled study using specific multiplex PCR combined with DNA microarray primer extension. Experimental Dermatology
Online publication date: 1-Apr-2009.
CrossRef
Botjan J. Kocjan, Katja Seme, Mojca Cimerman, Anja Kovanda, Marko Potonik, Mario Poljak. (2009) Genomic diversity of human papillomavirus (HPV) Genotype 38. Journal of Medical Virology 81:2, 288-295
Online publication date: 1-Mar-2009.
CrossRef
A. Handisurya, R. Gambhira, C. Schellenbacher, S. Shafti-Keramat, O. Forslund, M. Favre, R. Kirnbauer. (2009) Serological relationship between cutaneous human papillomavirus types 5, 8 and 92. Journal of General Virology 90:1, 136-143
Online publication date: 1-Feb-2009.
CrossRef
Nancy Crum-Cianflone, Katherine Huppler Hullsiek, Vincent Marconi, Amy Weintrob, Anuradha Ganesan, R Vincent Barthel, Susan Fraser, Brian K Agan, Scott Wegner. (2009) Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS 23:1, 41-50
Online publication date: 1-Feb-2009.
CrossRef
Delphine Casabonne, Aoife Lally, Liza Mitchell, Kristina M. Michael, Tim Waterboer, Michael Pawlita, Beata Imko-Walczuk, Fenella Wojnarowska, Charlotte Proby, Catherine Harwood, Robert Newton. (2009) A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors. International Journal of Cancer NA-NA
Online publication date: 1-Feb-2009.
CrossRef
Emilie Lanoy, Graça M Dores, Margaret M Madeleine, Jorge R Toro, Joseph F Fraumeni, Eric A Engels. (2009) Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 23:3, 385-393
Online publication date: 1-Feb-2009.
CrossRef
Anita S Patel, Margaret R Karagas, Ann E Perry, Heather H Nelson. (2009) Exposure Profiles and Human Papillomavirus Infection in Skin Cancer: An Analysis of 25 Genus β-Types in a Population-Based Study. Journal of Investigative Dermatology 128:12, 2888-2893
Online publication date: 1-Jan-2009.
CrossRef
Dana E. Rollison, Michael Pawlita, Anna R. Giuliano, Michelle R. Iannacone, Vernon K. Sondak, Jane L. Messina, C. Wayne Cruse, Neil Alan Fenske, Lewis Frank Glass, Matthew Kienstra, Kristina M. Michael, Tim Waterboer, Tarik Gheit, Massimo Tommasino. (2008) Measures of cutaneous human papillomavirus infection in normal tissues as biomarkers of HPV in corresponding nonmelanoma skin cancers. International Journal of Cancer 123:10, 2337-2342
Online publication date: 15-Dec-2008.
CrossRef
A. C.-H. Chen, N. A. J. McMillan, A. Antonsson. (2008) Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. Journal of General Virology 89:11, 2891-2897
Online publication date: 1-Dec-2008.
CrossRef
N. Vasiljevic, K. Hazard, J. Dillner, O. Forslund. (2008) Four novel human betapapillomaviruses of species 2 preferentially found in actinic keratosis. Journal of General Virology 89:10, 2467-2474
Online publication date: 1-Nov-2008.
CrossRef
John S. Munday, Matti Kiupel, Adrienne F. French, Laryssa Howe. (2008) Amplification of papillomaviral DNA sequences from a high proportion of feline cutaneous in situ and invasive squamous cell carcinomas using a nested polymerase chain reaction. Veterinary Dermatology 19:5, 259-263
Online publication date: 1-Nov-2008.
CrossRef
T. Waterboer, D. Abeni, F. Sampogna, A. Rother, C. Masini, P. Sehr, K.M. Michael, M. Pawlita. (2008) Serological association of beta and gamma human papillomaviruses with squamous cell carcinoma of the skin. British Journal of Dermatology 159:2, 457-459
Online publication date: 1-Sep-2008.
CrossRef
Jian-Wei Fei, Ethel-Michele de Villiers. (2008) Degradation of HPV20E6 by p53: ΔNp63α and mutant p53R248W protect the wild type p53 mediated caspase-degradation. International Journal of Cancer 123:1, 108-116
Online publication date: 1-Aug-2008.
CrossRef
Maryam M Asgari, Nancy B Kiviat, Cathy W Critchlow, Joshua E Stern, Zsolt B Argenyi, Gregory J Raugi, Daniel Berg, Peter B Odland, Stephen E Hawes, Ethel-Michele de Villiers. (2008) Detection of Human Papillomavirus DNA in Cutaneous Squamous Cell Carcinoma among Immunocompetent Individuals. Journal of Investigative Dermatology 128:6, 1409-1417
Online publication date: 1-Jul-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Presented in part: 23rd International Papillomavirus Conference, Prague, Czech Republic, 6 September 2006 [abstract PS 28‐6].

    Financial support: European Commission (grant “Viraskin” QLK2‐CT‐2002‐01500); Swedish Research Council; Swedish Cancer Society.

  • Study group members are listed after the text.

Back to Top
Close Popup