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1 October 2007

Volume 196, Number 7
The Journal of Infectious Diseases 2007;196:1053–1057
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19607-0017$15.00
DOI: 10.1086/520935
BRIEF REPORT

Elevated Serum Levels of Interferon‐γ–Inducible Protein–10 in Patients Coinfected with Hepatitis C Virus and HIV

Barbara Roe,1

Suzie Coughlan,2

Jaythoon Hassan,2

Anne Grogan,4

Gillian Farrell,3

Suzanne Norris,4

Colm Bergin,3 and

William W. Hall1,2

1Centre for Research in Infectious Diseases and 2National Virus Reference Laboratory, School of Medicine and Medical Sciences, University College Dublin, and 3Department of Genitourinary Medicine and Infectious Diseases and 4Hepatology Centre, St. James’s Hospital, Dublin, Ireland

Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts—HCV/HIV‐coinfected patients, HCV‐monoinfected patients, HIV‐monoinfected patients, and healthy control subjects—were studied. Serum levels of the 10‐kDa interferon‐γ–inducible protein (IP‐10) were higher in all 3 groups of infected patients than in control subjects ( ). HCV/HIV‐coinfected patients had significantly higher IP‐10 levels than monoinfected patients. In HCV‐monoinfected patients, liver fibrosis scores and liver enzyme levels were positively correlated with IP‐10 levels. Elevated IP‐10 levels are associated with and may contribute to liver damage in both HCV‐monoinfected and HCV/HIV‐coinfected patients.

Received 29 January 2007; accepted 8 April 2007; electronically published 21 August 2007.

Reprints or correspondence: Dr. William W. Hall, Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland ().

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Barbara Roe, William W. Hall. (2008) Cellular and molecular interactions in coinfection with hepatitis C virus and human immunodeficiency virus. Expert Reviews in Molecular Medicine 10,
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  • Potential conflicts of interest: none reported.

    Financial support: National Virus Reference Laboratory, University College Dublin, Ireland (grant 8090).

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