All Journals > Clinical Infectious Diseases > 1 September 2007 > CD4 Cell Percentage as a Marker of Immunosuppression

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 September 2007

Volume 45, Number 5
Clinical Infectious Diseases 2007;45:650–653
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4505-0020$15.00
DOI: 10.1086/520025
HIV/AIDS BRIEF REPORT

Is the CD4 Cell Percentage a Better Marker of Immunosuppression than the Absolute CD4 Cell Count in HIV‐Infected Patients with Cirrhosis?

Marco Bongiovanni,1

Andrea Gori,1

Alessandro Cozzi Lepri,7

Andrea Antinori,2

Andrea de Luca,3

Gabriella Pagano,4

Alessandro Chiodera,5

Massimo Puoti,6 and

Antonella d’Arminio Monforte,1 for the

Italian Cohort of Antiretroviral‐Naive Patients Study Groupa

1Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, 2National Institute of Infectious Diseases, L. Spallanzani, IRCCS, and 3Institute of Infectious Diseases, University Cattolica del Sacro Cuore, Rome, 4Division of Infectious Diseases, San Martino Hospital, Genova, 5Division of Infectious Diseases, Macerata Hospital, Macerata, and 6Clinic of Infectious Diseases, University of Brescia, Brescia, Italy; and 7Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom

Recently, it was shown that cirrhotic patients without human immunodeficiency virus (HIV) infection had low CD4 cell counts and normal CD4 cell percentages, suggesting that, for HIV‐infected persons, the CD4 cell percentage might be a more accurate marker of disease progression than the absolute CD4 cell count. In cirrhotic HIV‐infected persons in the Italian Cohort of Antiretroviral‐Naive Patients, the absolute CD4 cell count seemed to be better predictor of the risk of developing an acquired immunodeficiency syndrome–defining illness than the CD4 cell percentage.

Received 7 February 2007; accepted 11 April 2007; electronically published 1 August 2007.

Reprints or correspondence: Dr. Marco Bongiovanni, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, via di Rudinì 8, 20142 Milan, Italy ().

  • Members of the study group are listed at the end of the text.

Back to Top
Close Popup