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15 August 2007

Volume 45, Number 4
Clinical Infectious Diseases 2007;45:e39–e41
1058-4838/2007/4504-00E2$15.00
DOI: 10.1086/520015
BRIEF REPORT

The Safety and Efficacy of Enfuvirtide Therapy for HIV Infection in Patients with Hemophilia: A Case Series

Mark N. Polizzotto,1

Alison M. Street,1,3 and

Edwina Wright2,3

Departments of 1Haematology and 2Infectious Diseases and 3Ronald Sawyers Haemophilia Centre, The Alfred Hospital, Melbourne, Australia

The treatment of patients with human immmunodeficiency virus (HIV) infection and hemophilia involves unique challenges that may be addressed with novel antiretroviral classes. We describe the safety and efficacy of enfuvirtide therapy in 4 patients with severe hemophilia A. Although local skin reactions were common, neither local nor systemic bleeding worsened. Three patients achieved undetectable HIV loads with enfuvirtide salvage regimens.

Received 27 February 2007; accepted 19 April 2007; electronically published 6 July 2007.

Reprints or correspondence: Dr. Edwina Wright, Dept. of Infectious Diseases, The Alfred Hospital, 1 Commercial Rd., Melbourne, Australia 3004 ().

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Online publication date: 1-Oct-2008.
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(2008) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 17:3, i-xii
Online publication date: 1-Apr-2008.
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