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15 August 2007

Volume 196, Number 4
The Journal of Infectious Diseases 2007;196:505–509
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19604-0004$15.00
DOI: 10.1086/519693
BRIEF REPORT

Polymorphisms in TLR2 Are Associated with Increased Viral Shedding and Lesional Rate in Patients with Genital Herpes Simplex Virus Type 2 Infection

Pierre‐Yves Bochud,1,2

Amalia S. Magaret,3,4

David M. Koelle,2,4,5

Alan Aderem,1,a and

Anna Wald2,4,5,6,a

1Institute for Systems Biology, 2Programs in Infectious Diseases and 3Biostatistics, Fred Hutchinson Cancer Research Center, and 4Departments of Laboratory Medicine, 5Medicine, and 6Epidemiology, University of Washington, Seattle

Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV‐2) infection vary widely. We examined frequencies of single‐nucleotide polymorphisms (SNPs) in Toll‐like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV‐2–infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional ( and ) and shedding ( and ) rates. An SNP in haplotype 2 (−15607A/G) was also associated with shedding ( ) and lesional ( ) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV‐2 infection.

Received 11 January 2007; accepted 6 February 2007; electronically published 29 June 2007.

Reprints or correspondence: Dr. Pierre‐Yves Bochud, Institute for Systems Biology, 1441 N 34th St., Seattle, WA 98103 ().

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  • Potential conflicts of interest: none reported.

    Financial support: Swiss Foundation for Medical and Biological (grant 1121 to P.‐Y.B.); Swiss National Science Foundation (grant 81LA‐65462 to P.‐Y.B.); National Institutes of Health (grants AI‐31448 and AI‐030731 to A.W. and D.M.K., grant AI‐071113 to A.W., and grant AI50132 to D.M.K.).

  • A.A. and A.W. contributed equally to the article.

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