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1 August 2007

Volume 196, Number 3
The Journal of Infectious Diseases 2007;196:485–492
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19603-0020$15.00
DOI: 10.1086/519389
MAJOR ARTICLE

Generation and Characterization of Anti‐Candida T Cells as Potential Immunotherapy in Patients with Candida Infection after Allogeneic Hematopoietic Stem‐Cell Transplant

Lars Tramsen,1

Olaf Beck,1

Friedhelm R. Schuster,3,4

Klaus‐Peter Hunfeld,2

Jean‐Paul Latgé,5

Jacqueline Sarfati,5

Frauke Röger,1

Thomas Klingebiel,1

Ulrike Koehl,1 and

Thomas Lehrnbecher1

1Pediatric Hematology and Oncology and 2Institute of Medical Microbiology and Infection Control, Johann Wolfgang Goethe University, Frankfurt, 3Pediatric Hematology and Oncology, Dr. von Haunersches Children’s Hospital, Ludwig Maximilians University Munich, Munich, and 4Clinics of Pediatric Oncology, Hematology and Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany; 5Insitut Pasteur, Paris, France

Because lymphocytes play a major role in the host response to Candida infection, adoptive transfer of anti‐Candida T cells might be a therapeutic option in patients undergoing allogeneic hematopoietic stem‐cell transplant (alloHSCT) who have invasive Candida infection. Using the interferon (IFN)–γ secretion assay, we isolated human anti‐Candida T cells after stimulation with a cellular extract of C. albicans. These cells were expanded within 4 weeks to an average number of T helper 1 type lymphocytes and significantly lost their alloreactive potential, compared with the original cell population. The generated cells were also stimulated by antigens of C. tropicalis but not by antigens of C. glabrata or various molds. In addition, generated anti‐Candida T cells were able to induce damage to C. albicans hyphae and significantly increased hyphal damage induced by human neutrophils. Our data suggest that the generation of functionally active anti‐Candida T cells is feasible and may be a promising treatment option for patients undergoing alloHSCT.

Received 20 December 2006; accepted 7 March 2007; electronically published 18 June 2007.

Reprints or correspondence: Dr. Thomas Lehrnbecher, Pediatric Hematology and Oncology, Children’s Hospital III, Johann Wolfgang Goethe University, Theodor‐Stern‐Kai 7, D‐60590 Frankfurt, Germany ().

Cited by

L Tramsen, U Koehl, T Tonn, J-P Latgé, F R Schuster, A Borkhardt, L Uharek, R Quaritsch, O Beck, E Seifried, T Klingebiel, T Lehrnbecher. (2008) Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy. Bone Marrow Transplantation
Online publication date: 1-Oct-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Presented in part: 48th Annual Meeting of the American Society of Hematology, Orlando, 9–11 December 2006 (abstract 3226).

    Financial support: Nachlässe Marie Christine Held und Erika Hecker; Elterninitiative Intern 3; Bettina‐Bräu‐Stiftung.

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