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1 August 2007

Volume 45, Number 3
Clinical Infectious Diseases 2007;45:315–321
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4503-0007$15.00
DOI: 10.1086/519263
MAJOR ARTICLE

Factors Predicting Mortality in Necrotizing Community‐Acquired Pneumonia Caused by Staphylococcus aureus Containing Panton‐Valentine Leukocidin

Yves Gillet,1,2,3

Philippe Vanhems,1,3,4

Gerard Lina,1,2,3

Michèle Bes,1,2,3

François Vandenesch,1,2,3

Daniel Floret,1,3 and

Jerome Etienne1,2,3

1Université de Lyon 1, 2Inserm U851, Faculté Laennec, Centre National de Référence des Staphylocoques, and 3Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, and 4Unité Mixte de Recherche, Centre National de la Recherche Scientifique 5558, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France

Background.Necrotizing pneumonia due to Panton‐Valentine leukocidin–producing strains of Staphylococcus aureus is associated with a high mortality rate. We sought factors associated with vital outcome in 50 cases occurring from 1986 through 2005.

Methods.We compared the clinical and biological characteristics of 50 patients according to their vital outcome and examined the characteristics of the corresponding S. aureus isolates.

Results.The overall mortality rate was 56%, and the median survival time was 10 days. All of the deaths were attributed to S. aureus infection and were secondary to refractory shock and/or respiratory failure. Fatal outcome was associated with classical severity factors, such as the need for mechanical ventilation or inotrope support, and with onset of the acute respiratory distress syndrome. Airway bleeding was strongly associated with fatal outcome ( ). Patients who had focal staphylococcal infection before the onset of pneumonia had a significantly lower mortality rate ( ). The main biological feature associated with death was leukopenia ( ). In multivariate analysis, leukopenia and erythroderma occurring within the first 24 h after admission to the hospital were independently associated with fatal outcome. Erythroderma was not associated with toxic shock syndrome toxin.

Conclusions.Airway bleeding, erythroderma, and leukopenia are associated with fatal outcome from Panton‐Valentine leukocidin–positive S. aureus necrotizing pneumonia. More work is needed to develop more efficacious therapy against this highly lethal disease.

Received 2 February 2007; accepted 18 April 2007; electronically published 15 June 2007.

Reprints or correspondence: Dr. Jerome Etienne, Université de Lyon, Inserm U851, Faculté de Médecine Laennec, 7 rue Guillaume Paradin, 69372 Lyon, Cedex 08, France ().

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