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15 July 2007

Volume 45, Number 2
Clinical Infectious Diseases 2007;45:263–266
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4502-0020$15.00
DOI: 10.1086/518973
HIV/AIDS BRIEF REPORT

Efavirenz to Nevirapine Switch in HIV‐1–Infected Patients with Dyslipidemia: A Randomized, Controlled Study

Jean‐Jacques Parienti,1,2,3

Véronique Massari,1,2

David Rey,5

Patrice Poubeau,6 and

Renaud Verdon,4 for the

SIROCCO study teama

1Epidémiologie, Systèmes d’Informations, Modélisation, Institut National de la Santé et de la Recherche Médicale U707, 2Unité Mixte et de Recherche‐S707, Université Pierre et Marie Curie‐Paris 6, Paris, Departments of 3Biostatistics and Clinical Research and 4Infectious Diseases, Côte de Nacre University Hospital, Caen, 5Infectious Diseases Department, Hôpitaux Universitaires, Strasbourg, and 6Infectious Diseases Department, Hôpital St Pierre, Saint‐Pierre La Réunion, France

Many antiretroviral therapies, including efavirenz, are associated with increased serum concentrations of low‐density lipoprotein cholesterol. In a small 52‐week randomized study, we found that switching from efavirenz to nevirapine was associated with significantly decreased low‐density lipoprotein cholesterol levels, compared with continuation of efavirenz therapy ( ). A switch to nevirapine was associated with no severe adverse events.

Received 26 December 2006; accepted 12 March 2007; electronically published 6 June 2007.

Reprints or correspondence: Dr. Jean‐Jacques Parienti, Service de maladies infectieuses et tropicales, Niveau 16, CHU Côte de Nacre, 14033 Caen, France ().

Cited by

Amy M Bain, Elizabeth A White, William S Rutherford, Anita P Rahman, Anthony J Busti. (2008) A Multimodal, Evidence-Based Approach to Achieve Lipid Targets in the Treatment of Antiretroviral-Associated Dyslipidemia: Case Report and Review of the Literature. Pharmacotherapy 28:7, 932-938
Online publication date: 1-Aug-2008.
CrossRef
(2008) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 17:2, i-xii
Online publication date: 1-Mar-2008.
CrossRef
Caroline A Sabin. (2008) Cardiovascular risk and choice of HIV drug regimen. Future HIV Therapy 2:1, 83-92
Online publication date: 1-Feb-2008.
CrossRef

  • Members of the SIROCCO study team are listed at the end of the text.

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