All Journals > The Journal of Infectious Diseases > 1 July 2007 > HIV Infection and MDR‐TB

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 July 2007 Supplement

Volume 196, Number S1
The Journal of Infectious Diseases 2007;196:S86–S107
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19604S1-0011$15.00
DOI: 10.1086/518665
SUPPLEMENT ARTICLE

HIV Infection and Multidrug‐Resistant Tuberculosis—The Perfect Storm

Charles D. Wells,1

J. Peter Cegielski,1

Lisa J. Nelson,2

Kayla F. Laserson,3

Timothy H. Holtz,1

Alyssa Finlay,1

Kenneth G. Castro,1 and

Karin Weyer4

1Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia; 2Global AIDS Program–Mozambique, CDC, Maputo, Mozambique; 3Kenya Medical Research Institute/CDC Research Center, Kisumu, Kenya; 4Medical Research Council of South Africa, Pretoria, South Africa

Background.Multidrug‐resistant (MDR) tuberculosis (TB) has emerged as a global epidemic, with 425,000 new cases estimated to occur annually. The global human immunodeficiency virus (HIV) infection epidemic has caused explosive increases in TB incidence and may be contributing to increases in MDR‐TB prevalence.

Methods.We reviewed published studies and available surveillance data evaluating links between HIV infection and MDR‐TB to quantify convergence of these 2 epidemics, evaluate the consequences, and determine essential steps to address these epidemics.

Results.Institutional outbreaks of MDR‐TB have primarily affected HIV‐infected persons. Delayed diagnosis, inadequate initial treatment, and prolonged infectiousness led to extraordinary attack rates and case‐fatality rates among HIV‐infected persons. Whether this sequence occurs in communities is less clear. MDR‐TB appears not to cause infection or disease more readily than drug‐susceptible TB in HIV‐infected persons. HIV infection may lead to malabsorption of anti‐TB drugs and acquired rifamycin resistance. HIV‐infected patients with MDR‐TB have unacceptably high mortality; both antiretroviral and antimycobacterial treatment are necessary. Simultaneous treatment requires 6–10 different drugs. In HIV‐prevalent countries, TB programs struggle with increased caseloads, which increase the risk of acquired MDR‐TB. Surveillance data suggest that HIV infection and MDR‐TB may converge in several countries.

Conclusions.Institutional outbreaks, overwhelmed public health programs, and complex clinical management issues may contribute to the convergence of the MDR‐TB and HIV infection epidemics. To forestall disastrous consequences, infection control, rapid case detection, effective treatment, and expanded program capacity are needed urgently.

Reprints or correspondence: Dr. Charles D. Wells, International Research and Programs Branch, Div. of Tuberculosis Elimination, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333 ().

Cited by

Stephen D Lawn, Gavin Churchyard. (2009) Epidemiology of HIV-associated tuberculosis. Current Opinion in HIV and AIDS 4:4, 325-333
Online publication date: 1-Aug-2009.
CrossRef
S. Basu, G. H. Friedland, J. Medlock, J. R. Andrews, N. S. Shah, N. R. Gandhi, A. Moll, P. Moodley, A. W. Sturm, A. P. Galvani. (2009) Averting epidemics of extensively drug-resistant tuberculosis. Proceedings of the National Academy of Sciences 106:18, 7672-7677
Online publication date: 5-Jun-2009.
CrossRef
Janet R. Maurer. (2009) Extensively drug-resistant tuberculosis: Lessons from the US experience. Current Infectious Disease Reports 11:3, 173-174
Online publication date: 1-Jun-2009.
CrossRef
Nicolas Willand, Bertrand Dirié, Xavier Carette, Pablo Bifani, Amit Singhal, Matthieu Desroses, Florence Leroux, Eve Willery, Vanessa Mathys, Rebecca Déprez-Poulain, Guy Delcroix, Frédéric Frénois, Marc Aumercier, Camille Locht, Vincent Villeret, Benoit Déprez, Alain R Baulard. (2009) Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nature Medicine 15:5, 537-544
Online publication date: 1-Jun-2009.
CrossRef
I. Suárez-García, A. Rodríguez-Blanco, J. L. Vidal-Pérez, M. A. García-Viejo, M. J. Jaras-Hernández, O. López, A. Noguerado-Asensio. (2009) Risk factors for multidrug-resistant tuberculosis in a tuberculosis unit in Madrid, Spain. European Journal of Clinical Microbiology & Infectious Diseases 28:4, 325-330
Online publication date: 1-May-2009.
CrossRef
Haileyesus Getahun, Diane Havlir, Reuben Granich, Alasdair Reid, Ernesto Jaramillo, Paul Nunn. (2009) Paradigm shift to address drug resistant tuberculosis in people living with HIV needed, and needed now. Tropical Medicine & International Health 14:4, 376-378
Online publication date: 1-May-2009.
CrossRef
Gerald Friedland. (2009) Editorial Commentary: Tuberculosis Immune Reconstitution Inflammatory Syndrome: Drug Resistance and the Critical Need for Better Diagnostics. Clinical Infectious Diseases 48:5, 677-679
Online publication date: 1-Mar-2009.
Citation-Full Text-PDF Version (186 kB)
Graeme Meintjes, Molebogeng X. Rangaka, Gary Maartens, Kevin Rebe, Chelsea Morroni, Dominique J. Pepper, Katalin A. Wilkinson, and Robert J. Wilkinson. (2009) Novel Relationship between Tuberculosis Immune Reconstitution Inflammatory Syndrome and Antitubercular Drug Resistance. Clinical Infectious Diseases 48:5, 667-676
Online publication date: 1-Mar-2009.
Abstract-Full Text-PDF Version (340 kB)
Sheela Shenoi, Scott Heysell, Anthony Moll, Gerald Friedland. (2009) Multidrug-resistant and extensively drug-resistant tuberculosis: consequences for the global HIV community. Current Opinion in Infectious Diseases 22:1, 11-17
Online publication date: 1-Mar-2009.
CrossRef
S. BASU, A. P. GALVANI. (2009) The transmission and control of XDR TB in South Africa: an operations research and mathematical modelling approach. Epidemiology and Infection 136:12, 1585
Online publication date: 1-Jan-2009.
CrossRef
Andrea T Cruz, Jeffrey R Starke. (2009) Treatment of tuberculosis in children. Expert Review of Anti-infective Therapy 6:6, 939-957
Online publication date: 1-Jan-2009.
CrossRef
Jason R. Andrews, Neel R. Gandhi, Prashini Moodley, N. Sarita Shah, Louise Bohlken, Anthony P. Moll, Manormoney Pillay, Gerald Friedland, and A. Willem Sturm on behalf of the Tugela Ferry Care and Research Collaboration. (2008) Exogenous Reinfection as a Cause of Multidrug‐Resistant and Extensively Drug‐Resistant Tuberculosis in Rural South Africa. The Journal of Infectious Diseases 198:11, 1582-1589
Online publication date: 1-Dec-2008.
Abstract-Full Text-PDF Version (252 kB)
Beatriz Manzor Mitrzyk. (2008) Treatment of Extensively Drug-Resistant Tuberculosis and Role of the Pharmacist. Pharmacotherapy 28:10, 1243-1254
Online publication date: 1-Nov-2008.
CrossRef
Paul Yager, Gonzalo J. Domingo, John Gerdes. (2008) Point-of-Care Diagnostics for Global Health. Annual Review of Biomedical Engineering 10:1, 107-144
Online publication date: 1-Sep-2008.
CrossRef
Ben Cheng, Alan Landay, Veronica Miller. (2008) Research needs and challenges in the development of HIV diagnostic and treatment monitoring tests for use in resource-limited settings. Current Opinion in HIV and AIDS 3:4, 495-503
Online publication date: 1-Aug-2008.
CrossRef
Howard M. Shapiro, Nancy G. Perlmutter. (2008) Killer applications: Toward affordable rapid cell-based diagnostics for malaria and tuberculosis. Cytometry Part B: Clinical Cytometry 74B:S1, S152-S164
Online publication date: 1-Feb-2008.
CrossRef
Roderick J. Hay. (2008) Cutaneous Tuberculosis and the Control of Infection in Resource-Poor Environments. Dermatology 217:1, 94-96
Online publication date: 1-Feb-2008.
CrossRef
Jason R. Andrews, N. Sarita Shah, Neel Gandhi, Tony Moll, and Gerald Friedland, on behalf of the Tugela Ferry Care and Research (TF CARES) Collaboration. (2007) Multidrug‐Resistant and Extensively Drug‐Resistant Tuberculosis: Implications for the HIV Epidemic and Antiretroviral Therapy Rollout in South Africa. The Journal of Infectious Diseases 196:s3, S482-S490
Online publication date: 1-Dec-2007.
Abstract-Full Text-PDF Version (222 kB)
Stephen D Lawn, David J Edwards, Robin Wood. (2007) Concurrent drug therapy for tuberculosis and HIV infection in resource-limited settings: present status and future prospects. Future HIV Therapy 1:4, 387-398
Online publication date: 1-Dec-2007.
CrossRef
Alberto Matteelli, Giovanni Battista Migliori, Daniela Cirillo, Rosella Centis, Enrico Girard, Mario Raviglione. (2007) Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control. Expert Review of Anti-infective Therapy 5:5, 857-871
Online publication date: 1-Nov-2007.
CrossRef
Gerald Friedland, Gavin J. Churchyard, and Edward Nardell. (2007) Introduction: Tuberculosis and HIV Coinfection: Current State of Knowledge and Research Priorities. The Journal of Infectious Diseases 196:s1, S1-S3
Online publication date: 1-Jul-2007.
Citation-Full Text-PDF Version (183 kB)
Gerald Friedland, Anthony Harries, and David Coetzee. (2007) Implementation Issues in Tuberculosis/HIV Program Collaboration and Integration: 3 Case Studies. The Journal of Infectious Diseases 196:s1, S114-S123
Online publication date: 1-Jul-2007.
Abstract-Full Text-PDF Version (239 kB)

  • Potential conflicts of interest: none reported.

    Financial support: US government; resources were provided solely in the form of staff time dedicated to conducting this project. Supplement sponsorship is detailed in the Acknowledgments.

    The findings and conclusions in this report are those of the authors and do not necessarily reflect the views of the Centers for Disease Control and Prevention.

Back to Top
Close Popup