Article Tools

Search for Related Articles

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 July 2007 Supplement

Volume 196, Number S1
The Journal of Infectious Diseases 2007;196:S28–S34
0022-1899/2007/19604S1-0005$15.00
DOI: 10.1086/518663
SUPPLEMENT ARTICLE

New Tuberculosis Therapeutics: A Growing Pipeline

Melvin K. Spigelman

The Global Alliance for TB Drug Development, New York, New York

Novel chemotherapeutic drugs are needed to improve tuberculosis (TB) control, especially in the developing world. Given the magnitude of the problem and the resources available in countries that have the highest burden of disease, the present standards of care for the treatment of drug‐susceptible TB, drug‐resistant TB, TB/human immunodeficiency virus (HIV) coinfection, and latent TB infection are all unsatisfactory. Because no truly novel compounds for the treatment of TB have been discovered in the past 40 years, the recent enhanced activity in the research and development of new TB drugs is extremely encouraging. Seven compounds are presently in clinical development specifically for the treatment of TB. Other known antibiotic compound families are being investigated preclinically, in an attempt to identify new antimicrobial drugs with specific antituberculous activity. In addition, novel targets have been identified and are the subject of efforts to validate their potential usefulness in the treatment of TB.

Reprints or correspondence: Dr. Melvin K. Spigelman, The Global Alliance for TB Drug Development, 80 Broad St., 31st Fl., New York, NY 10004 ().

Cited by

Donald E. Low. (2009) Editorial Commentary: Fluoroquinolones for Treatment of Community‐Acquired Pneumonia and Tuberculosis: Putting the Risk of Resistance into Perspective. Clinical Infectious Diseases 48:10, 1361-3
Online publication date: 15-May-2009.
Alejandro Speck Planche, Marcus Tulius Scotti, América García López, Vicente Paulo Emerenciano, Enrique Molina Pérez, Eugenio Uriarte. (2009) Design of novel antituberculosis compounds using graph-theoretical and substructural approaches. Molecular Diversity
Online publication date: 2-May-2009.
CrossRef
Palaniappan Senthilkumar, Murugesan Dinakaran, Yogesh Chandraseakaran, Perumal Yogeeswari, Dharmarajan Sriram. (2009) Synthesis and in-vitro Antimycobacterial Evaluation of 1-(Cyclopropyl/2,4-difluorophenyl/ tert- butyl)-1,4-dihydro- 8-methyl-6-nitro-4-oxo-7-(substituted secondary amino)quinoline-3-carboxylic acids. Archiv der Pharmazie 342:2, 100-112
Online publication date: 1-Mar-2009.
CrossRef
Jerrold J. Ellner. (2009) The Emergence of Extensively Drug-Resistant Tuberculosis: A Global Health Crisis Requiring New Interventions: Part II: Scientific Advances that May Provide Solutions. Clinical and Translational Science 2:1, 80-84
Online publication date: 1-Mar-2009.
CrossRef
Christopher Dye. (2009) Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis. Nature Reviews Microbiology 7:1, 81-87
Online publication date: 1-Feb-2009.
CrossRef
Jerrold J. Ellner. (2009) The Emergence of Extensively Drug-Resistant Tuberculosis: A Global Health Crisis Requiring New Interventions: Part II: Scientific Advances that May Provide Solutions. Clinical and Translational Science
Online publication date: 1-Feb-2009.
CrossRef
Andrea T Cruz, Jeffrey R Starke. (2009) Treatment of tuberculosis in children. Expert Review of Anti-infective Therapy 6:6, 939-957
Online publication date: 1-Jan-2009.
CrossRef
Edward D Chan, Michael D Iseman. (2009) Multidrug-resistant and extensively drug-resistant tuberculosis: a review. Current Opinion in Infectious Diseases 21:6, 587-595
Online publication date: 1-Jan-2009.
CrossRef
Ritu Banerjee, Gisela F Schecter, Jennifer Flood, Travis C Porco. (2008) Extensively drug-resistant tuberculosis: new strains, new challenges. Expert Review of Anti-infective Therapy 6:5, 713-724
Online publication date: 1-Nov-2008.
CrossRef
Claudia Wallrauch, Till Bärnighausen, Tom Heller, Catherine Houlihan, Marie-Louise Newell. (2008) The white and the three-letter plague: integration of TB and HIV care in sub-Saharan Africa. Future HIV Therapy 2:5, 437-451
Online publication date: 1-Oct-2008.
CrossRef
Cheuk-Ming TAM. (2008) Development of new antituberculosis drugs: Its relevance worldwide and in the Asia-Pacific region. Respirology 13, S125-S131
Online publication date: 1-Oct-2008.
CrossRef
Haruaki Tomioka, Yutaka Tatano, Ko Yasumoto, Toshiaki Shimizu. (2008) Recent advances in antituberculous drug development and novel drug targets. Expert Review of Respiratory Medicine 2:4, 455-471
Online publication date: 1-Sep-2008.
CrossRef
J. G. Hurdle, R. B. Lee, N. R. Budha, E. I. Carson, J. Qi, M. S. Scherman, S. H. Cho, M. R. McNeil, A. J. Lenaerts, S. G. Franzblau, B. Meibohm, R. E. Lee. (2008) A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. Journal of Antimicrobial Chemotherapy 62:5, 1037-1045
Online publication date: 18-Aug-2008.
CrossRef
Srinivasa P.S. Rao, Luis Camacho, Bee Huat Tan, Calvin Boon, David G. Russel, Thomas Dick, Kevin Pethe. (2008) Recombinase-based reporter system and antisense technology to study gene expression and essentiality in hypoxic nonreplicating mycobacteria. FEMS Microbiology Letters 284:1, 68-75
Online publication date: 1-Aug-2008.
CrossRef
María S Sánchez, James O Lloyd-Smith, Travis C Porco, Brian G Williams, Martien W Borgdorff, John Mansoer, Joshua A Salomon, Wayne M Getz. (2008) Impact of HIV on novel therapies for tuberculosis control. AIDS 22:8, 963-972
Online publication date: 1-Jun-2008.
CrossRef
Marta Martins, Miguel Viveiros, Leonard Amaral. (2008) The TB laboratory of the future: macrophage-based selection of XDR-TB therapeutics. Future Microbiology 3:2, 135-144
Online publication date: 1-May-2008.
CrossRef
James C. Sacchettini, Eric J. Rubin, Joel S. Freundlich. (2008) Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nature Reviews Microbiology 6:1, 41-52
Online publication date: 1-Feb-2008.
CrossRef
Stephen D Lawn, David J Edwards, Robin Wood. (2007) Concurrent drug therapy for tuberculosis and HIV infection in resource-limited settings: present status and future prospects. Future HIV Therapy 1:4, 387-398
Online publication date: 1-Dec-2007.
CrossRef
Alberto Matteelli, Giovanni Battista Migliori, Daniela Cirillo, Rosella Centis, Enrico Girard, Mario Raviglione. (2007) Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control. Expert Review of Anti-infective Therapy 5:5, 857-871
Online publication date: 1-Nov-2007.
CrossRef
John G. Bartlett. (2007) Tuberculosis and HIV Infection: Partners in Human Tragedy. The Journal of Infectious Diseases 196:s1, S124-S125
Online publication date: 1-Jul-2007.
Gerald Friedland, Gavin J. Churchyard, and Edward Nardell. (2007) Introduction: Tuberculosis and HIV Coinfection: Current State of Knowledge and Research Priorities. The Journal of Infectious Diseases 196:s1, S1-S3
Online publication date: 1-Jul-2007.
  • Potential conflicts of interest: none reported.

    Financial support: supplement sponsorship is detailed in the Acknowledgments.

Close Popup