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1 July 2007 Supplement

Volume 196, Number S1
The Journal of Infectious Diseases 2007;196:S52–S62
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19604S1-0008$15.00
DOI: 10.1086/518662
SUPPLEMENT ARTICLE

Tuberculosis Preventive Therapy in the Era of HIV Infection: Overview and Research Priorities

Gavin J. Churchyard,1,2,3

Fabio Scano,4

Alison D. Grant,3 and

Richard E. Chaisson5

1Aurum Institute for Health Research, Marshalltown, and 2Centre for AIDS Programme of Research In South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa; 3London School of Hygiene and Tropical Medicine, London, United Kingdom; 4Stop TB Department, World Health Organization, Geneva, Switzerland; 5Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland

The recognition of tuberculosis (TB) as a major cause of morbidity and mortality among human immunodeficiency virus (HIV)–infected persons has led to renewed interest in TB preventive therapy and its incorporation into the essential package of health care for these individuals. Despite convincing data regarding its efficacy, TB preventive therapy has not been widely implemented. Further work is needed to determine how to overcome the barriers to the implementation of such therapy, including how best to exclude the presence of active TB before providing preventive therapy. Such issues as the optimal duration of preventive therapy for and the role of TB preventive therapy in the treatment of individuals receiving antiretroviral therapy remain to be defined. Ongoing research will help to determine how best to use this intervention in the care of HIV‐infected persons and in the control of TB on a wider basis.

Reprints or correspondence: Prof. Gavin J. Churchyard, Aurum Institute for Health Research, PO Box 61587, Marshalltown, Gauteng, 2107, South Africa ( or ).

Cited by

Stephen D Lawn, Anthony D Harries, Xavier Anglaret, Landon Myer, Robin Wood. (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS 22:15, 1897-1908
Online publication date: 1-Nov-2008.
CrossRef
Catherine Grossman, Jeffrey Kushinka, Lisa K. Brath. (2008) A 41-Year-Old Woman With AIDS, Mediastinal Lymphadenopathy, and Fever of Unknown Origin. The American Journal of the Medical Sciences 336:4, 349-352
Online publication date: 1-Nov-2008.
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Claudia Wallrauch, Till Bärnighausen, Tom Heller, Catherine Houlihan, Marie-Louise Newell. (2008) The white and the three-letter plague: integration of TB and HIV care in sub-Saharan Africa. Future HIV Therapy 2:5, 437-451
Online publication date: 1-Oct-2008.
CrossRef
Gerald Friedland, Gavin J. Churchyard, and Edward Nardell. (2007) Introduction: Tuberculosis and HIV Coinfection: Current State of Knowledge and Research Priorities. The Journal of Infectious Diseases 196:s1, S1-S3
Online publication date: 1-Jul-2007.
Citation-Full Text-PDF Version (183 kB)

  • Potential conflicts of interest: none reported.

    Financial support: UK Department of Health Public Health Career Scientist award (to A.D.G.); grants to G.J.C. from the Consortium to Respond Effectively to the AIDS/TB Epidemic (CREATE), the Mine Health Council, and the Centre for the AIDS Programme of Research in South Africa, which forms part of the Comprehensive International Program of Research on AIDS funded by the National Institute of Allergy and Infectious Diseases, the National Institutes of Health (NIH), and the US Department of Health and Human Services (grant 1 U19 AI51794). R.E.C. is supported by grants from the Bill and Melinda Gates Foundation (through CREATE) and the NIH (grant AI16137). Supplement sponsorship is detailed in the Acknowledgments.

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