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15 July 2007 Supplement

Volume 45, Number S1
Clinical Infectious Diseases 2007;45:S20–S23
1058-4838/2007/4502S1-0006$15.00
DOI: 10.1086/518135
SUPPLEMENT ARTICLE

CVD 908, CVD 908‐htrA, and CVD 909 Live Oral Typhoid Vaccines: A Logical Progression

Carol O. Tacket and

Myron M. Levine

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore

Typhoid fever remains an important public health problem in many parts of the world. Despite the availability of oral Ty21a (Vivotif; Berna Biotech) and parenteral Vi polysaccharide vaccine (Typhim Vi; Aventis Pasteur), improved typhoid fever vaccines have been sought. These include a series of vaccine candidates developed at the Center for Vaccine Development, University of Maryland, based on attenuation of Salmonella enterica serovar Typhi by deletions in the aroC, aroD, and htrA genes. These vaccine candidates, designated “CVD 908,” “CVD 908‐htrA,” and “CVD 909,” have been developed and tested in volunteers with variable success. This review summarizes the clinical data that directed the logical progression of this vaccine development strategy.

Reprints or correspondence: Dr. Carol O. Tacket, Center for Vaccine Development, University of Maryland School of Medicine, 685 W. Baltimore St., HSF1 Rm. 480, Baltimore, MD 21201 ().

Cited by

Jerry M. Wells, Annick Mercenier. (2008) Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nature Reviews Microbiology 6:5, 349-362
Online publication date: 1-Jun-2008.
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