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1 June 2007

Volume 44, Number 11
Clinical Infectious Diseases 2007;44:e96–e99
1058-4838/2007/4411-00E2$15.00
DOI: 10.1086/517513
BRIEF REPORT

Thalidomide Therapy for the Treatment of Hypertrophic Herpes Simplex Virus–Related Genitalis in HIV‐Infected Individuals

Andrea Holmes,1

Mairín McMenamin,2

Fiona Mulcahy,3 and

Colm Bergin3

1Department of Infectious Diseases, University of Texas Health Sciences Center at Houston; and Departments of 2Histopathology and 3Genitourinary Medicine and Infectious Diseases, St. James’s Hospital, Dublin, Ireland

Hypertrophic genital herpes is a disfiguring manifestation of a common infection seen in immunocompromised hosts that can be clinically mistaken for malignancy. We review the literature and describe hypertrophic genital herpes in a human immunodeficiency virus–positive patient receiving antiretroviral therapy. Treatment with valacyclovir, cidofovir, and foscarnet failed, but thalidomide treatment was successful.

Received 12 December 2006; accepted 12 February 2007; electronically published 18 April 2007.

Reprints or correspondence: Dr. Andrea Holmes, Infectious Diseases Fellow, University of Texas Health Sciences Center at Houston, 6431 Fannin, MSB 2.112, Houston, TX 77030 ().

Cited by

Leann Johnson, Joseph N. Jarvis, Edmund G. L. Wilkins, and Phillip E. Hay. (2008) Thalidomide Treatment for Refractory HIV‐Associated Colitis: A Case Series. Clinical Infectious Diseases 47:1, 133-136
Online publication date: 1-Jul-2008.
Mark H. Yudin, Rupert Kaul. (2008) Progressive Hypertrophic Genital Herpes in an HIV-Infected Woman despite Immune Recovery on Antiretroviral Therapy. Infectious Diseases in Obstetrics & Gynecology 2008, 1-5
Online publication date: 1-Feb-2008.
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