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1 June 2007

Volume 195, Number 11
The Journal of Infectious Diseases 2007;195:1618–1624
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19511-0010$15.00
DOI: 10.1086/516790
MAJOR ARTICLE

CD14 −550 C/T, Which Is Related to the Serum Level of Soluble CD14, Is Associated with the Development of Respiratory Syncytial Virus Bronchiolitis in the Japanese Population

Yuzaburo Inoue,1

Naoki Shimojo,1

Yoichi Suzuki,2

Eduardo Jose Campos Alberto,1

Akiko Yamaide,3

Shuichi Suzuki,3

Takayasu Arima,1

Tomoko Matsuura,4

Minako Tomiita,1

Masahiko Aoyagi,4

Akira Hoshioka,3

Akihito Honda,5

Akira Hata,2 and

Yoichi Kohno1

Departments of 1Pediatrics and 2Public Health, Graduate School of Medicine, Chiba University, 3Chiba Children’s Hospital, 4Shimosizu Hospital, and 5Asahi Central Hospital, Chiba, Japan

Background.The contribution that genetic polymorphisms of Toll‐like receptor (TLR) 4 and of CD14—both of which recognize respiratory syncytial virus (RSV) in the innate immune response—make to RSV bronchiolitis in the Japanese population has not yet been clarified.

Methods.This study genotyped 2 TLR4 mutations, Asp299Gly and Thr399Ile, and 2 single‐nucleotide polymorphisms (SNPs) of CD14, −550 C/T and −159 C/T, in 54 children with RSV bronchiolitis and in 203 control subjects. CD14 SNPs and the serum level of soluble CD14 (sCD14) also were examined in 67 cord‐blood specimens and in serum samples from 73 6‐year‐old children.

Results.No TLR4 mutations were found. The frequencies of both the CC genotype and the C allele of CD14 −550 C/T were significantly higher in children with RSV bronchiolitis than in the control subjects. The serum level of sCD14 was significantly higher in children with the CC genotype of CD14 −550 C/T than in those with the CT and TT genotypes.

Conclusions.CD14 −550 C/T, which is related to the serum level of sCD14, is associated with the development of RSV bronchiolitis in the Japanese population. This study's results indicate that, in different ethnic groups, different genetic factors contribute to the development of RSV bronchiolitis.

Received 5 October 2006; accepted 18 December 2006; electronically published 23 April 2007.

Reprints or correspondence: Dr. Yuzaburo Inoue, Dept. of Pediatrics, Graduate School of Medicine, Chiba University, 1–8‐1 Inohana Chuou‐ku, Chiba City, Chiba, Japan ().

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  • Potential conflicts of interest: none reported.

    Presented in part: World Allergy Congress 2005, 26 June–1 July 2005, Munich, Germany; 26th Symposium of the Collegium Internationale Allergologicum, 6–10 May 2006, St. Julians, Malta.

    Financial support: Ministry of Education, Culture, Sports, Science and Technology of Japan (grant‐in‐aid 16590975); Ministry of Health, Labour and Welfare of Japan (Sciences Research Grants of the Research on Allergic Disease and Immunology).

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