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1 May 2007

Volume 195, Number 9
The Journal of Infectious Diseases 2007;195:1283–1293
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19509-0009$15.00
DOI: 10.1086/513437
MAJOR ARTICLE

Molecular Epidemiology of HIV‐1 Infection and Full‐Length Genomic Analysis of Circulating Recombinant Form 07_BC Strains from Injection Drug Users in Taiwan

Yu‐Ting Lin,1,2,a

Yu‐Ching Lan,1,7,a

Yen‐Ju Chen,1,2

Yu‐Hui Huang,1,2

Cheng‐Ming Lee,1

Tze‐Tze Liu,3

Wing‐Wai Wong,5

Jyh‐Yuan Yang,6

Chin‐Tien Wang,2,4 and

Yi‐Ming Arthur Chen1,2

1AIDS Prevention and Research Center, 2Institute of Public Health, 3Genomics Research Center, and 4Institute of Clinical Medicine, National Yang‐Ming University, 5Branch of Disease Control, Taipei City Hospital, and 6Center for Disease Control, Taipei, and 7Department of Health Risk Management, China Medical University, Taichung, Taiwan

Background.Previously, we reported that there was an outbreak of human immunodeficiency virus type 1 (HIV‐1) circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan in 2004. The objectives of the present study were to conduct a molecular epidemiological analysis and to characterize the full‐length genome of the Taiwanese CRF07_BC.

Methods.Three hundred and fifty‐eight patients with HIV‐1/AIDS from hospitals and 133 HIV‐1–infected inmates from detention centers were recruited. DNA sequencing and phylogenetic analysis were conducted to determine subtypes and evolutionary relationships. Recombination breakpoints of 2 full‐length CRF07_BC strains were elucidated using a bootscanning method.

Results.Of 206 HIV‐1–infected patients who received a diagnosis in 2004, 44.7% were infected with subtype B, 53.4% with CRF07_BC, and 1.5% with CRF01_AE. Ninety‐eight percent (109/111) of IDUs were infected with CRF07_BC. Deletions of 7–11 amino acids in both p6gag and p6pol proteins were noted among the Taiwanese CRF07_BC strains. The CRF_07BC strains belonged to 2 phylogenetic clusters, and the first cluster contained only CRF07_BC strains from the southern part of Taiwan.

Conclusions.The Taiwanese CRF07_BC strains had 97% full‐length sequence homology with the prototype from mainland China. CRF07_BC was first introduced into the southern region in 2002 and then spread to other regions in Taiwan in 2004.

Received 9 August 2006; accepted 5 December 2006; electronically published 19 March 2007.

Reprints or correspondence: Prof. Yi‐Ming A. Chen, AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Noun St., Section 2, Taipei, Taiwan 112 ().

Cited by

Sheng-Fan Wang, Yuan-Ming Lee, Yu-Jiun Chan, Hsin-Fu Liu, Yung-Fong Yen, Wu-Tse Liu, Jason C. Huang, Yi-Ming Arthur Chen. (2009) Influenza A virus in Taiwan, 1980-2006: Phylogenetic and antigenic characteristics of the hemagglutinin gene. Journal of Medical Virology 81:8, 1457-1470
Online publication date: 1-Sep-2009.
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Online publication date: 1-Jun-2008.
Abstract-Full Text-PDF Version (443 kB)
Yu-Ching Lan, Tarek Elbeik, JoAnn Dileanis, Valerie Ng, Yen-Ju Chen, Hsieh-Shong Leu, Shu-Hsing Cheng, Jen-Chien Wong, Wing-Wai Wong, Yi-Ming A. Chen. (2008) Molecular epidemiology of HIV-1 subtypes and drug resistant strains in Taiwan. Journal of Medical Virology 80:2, 183-191
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Kok Keng Tee, Oliver G Pybus, Huanan Liao, Rie Uenishi, Saiki Hase, Adeeba Kamarulzaman, Xiao-Jie Li, Yutaka Takebe. (2008) Chronology of the HIV-1 CRF07_BC expansion in East Asia. AIDS 22:1, 156-158
Online publication date: 1-Feb-2008.
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Susan M Graham. (2007) Clinical impact of HIV-1 subtype: are there important differences?. Future HIV Therapy 1:3, 273-290
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  • Potential conflicts of interest: none reported.

    Presented in part: Seventh International Congress on AIDS in Asia and the Pacific, 1–5 July 2005, Kobe, Japan (abstract SaPA0037).

    Financial support: Center for Disease Control of the Department of Health of Taiwan (grants DOH93‐DC‐1043 and CDC94‐RM‐102); Veterans General Hospitals/University System of Taiwan and Tsou's Foundation (grant VGHUST93‐G7‐07‐1).

  • Y.‐T.L. and Y.‐C.L. contributed equally to this work.

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