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1 May 2007

Volume 44, Number 9
Clinical Infectious Diseases 2007;44:1245–1248
© 2007 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4409-0018$15.00
DOI: 10.1086/513433
HIV/AIDS BRIEF REPORT

Treatment Outcomes Stratified by Baseline Immunological Status among Young Children Receiving Nonnucleoside Reverse‐Transcriptase Inhibitor–Based Antiretroviral Therapy in Resource‐Limited Settings

Daniel P. O’Brien,1

Delphine Sauvageot,2

David Olson,1

Myrto Schaeffer,1

Pierre Humblet,1

Mar Pudjades,2

Tom Ellman,1

Rony Zachariah,1

Elisabeth Szumilin,1

Line Arnould,1 and

Tony Read,3 for

Médecins Sans Frontières

1AIDS Working Group, Médecins Sans Frontières; 2Epicentre, Paris, France; and 3Brussels Operational Centre, Médecins Sans Frontières, Brussels, Belgium

A study of 568 children aged <5 years who commenced nonnucleoside reverse‐transcriptase inhibitor–based antiretroviral therapy in resource‐limited settings revealed good early outcomes. After 12 months of antiretroviral therapy, survival probability was 0.89 (95% confidence interval, 0.86–0.92), with no significant difference among children stratified on the basis of baseline immunological levels; 62% attained a CD4 cell percentage >25%, and 7% continued to have a CD4 cell percentage <15%.

Received 26 November 2006; accepted 20 January 2007; electronically published 28 March 2007.

Reprints or correspondence: Dr. Daniel O’Brien, Médecins Sans Frontières, Plantage Middenlaan 14, 1001 EA, Amsterdam, The Netherlands ().

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