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1 April 2007

Volume 195, Number 7
The Journal of Infectious Diseases 2007;195:989–996
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19507-0012$15.00
DOI: 10.1086/512087
MAJOR ARTICLE

Bovine Spongiform Encephalopathy Agent in a Prion Protein (PrP)ARR/ARR Genotype Sheep after Peripheral Challenge: Complete Immunohistochemical Analysis of Disease‐Associated PrP and Transmission Studies to Ovine‐Transgenic Mice

Anna Bencsik and

Thierry Baron

Agence Française de Sécurité Sanitaire des Aliments, Unité Agents Transmissibles Non Conventionnels, Lyon, France

Possible transmission of the bovine spongiform encephalopathy (BSE) agent to ovine species has been considered for several years. It has been recently demonstrated that the BSE agent, after intracerebral challenge, can infect sheep believed to be the most resistant genetically to prion diseases (prion protein [PrP]ARR/ARR genotype). We report here the results of a detailed immunohistochemical analysis of the disease‐associated PrP (PrPd) in all organs from a PrPARR/ARR sheep infected with the BSE agent by a peripheral route. Because PrPd was detected in the brain in the absence of any clinical symptoms, transmission studies were also performed using a sensitive ovine‐transgenic mouse model—Tg(OvPrP4)—that can identify the BSE agent on the basis of the occurrence of florid plaques in the mouse brain. The data indicated that these PrPd deposits were linked to the BSE agent and were associated with infectivity. This suggests that PrPARR/ARR sheep may be silent carriers of the BSE agent.

Received 29 August 2006; accepted 2 October 2006; electronically published 16 February 2007.

Reprints or correspondence: Dr. Anna Bencsik, AFSSA, Unité ATNC, 31 ave. Tony Garnier, 69364 Lyon, cedex 07, France ().

Cited by

Marion Mathieson Simmons, John Spiropoulos, Stephen Anthony Charles Hawkins, Susan Jane Bellworthy, Susan Carol Tongue. (2008) Approaches to investigating transmission of spongiform encephalopathies in domestic animals using BSE as an example. Veterinary Research 1-18
Online publication date: 1-Aug-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: “Programme National de Recherches sur les ESST et les Prions” Groupement d'Intérêt Scientifique “Infections à Prions.”

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