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15 February 2007

Volume 195, Number 4
The Journal of Infectious Diseases 2007;195:597–601
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19504-0019$15.00
DOI: 10.1086/510910
BRIEF REPORT

Influence of Consecutive‐Day Blood Sampling on Polymerase Chain Reaction–Adjusted Parasitological Cure Rates in an Antimalarial‐Drug Trial Conducted in Tanzania

Andreas Mårtensson,1,3

Billy Ngasala,1,5

Johan Ursing,1

M. Isabel Veiga,1,6

Lisa Wiklund,1

Christopher Membi,5

Scott M. Montgomery,2,4

Zul Premji,5

Anna Färnert,1 and

Anders Björkman1

1Infectious Diseases Unit, Department of Medicine, and 2Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, 3Emergency Medicine Unit, Department of Medicine, Kullbergska Hospital, Katrineholm, and 4Clinical Research Centre, Örebro University Hospital, Örebro, Sweden; 5Department of Parasitology, Muhimbili Univerity College of Health Sciences, Dar es Salaam, Tanzania; 6Centre of Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal

We assessed the influence that consecutive‐day blood sampling, compared with single‐day blood sampling, had on polymerase chain reaction (PCR)–adjusted parasitological cure after stepwise genotyping of merozoite surface proteins 2 (msp2) and 1 (msp1) in 106 children in Tanzania who had uncomplicated falciparum malaria treated with either sulfadoxine‐pyrimethamine or artemether‐lumefantrine; 78 of these children developed recurrent parasitemia during the 42‐day follow‐up period. Initial msp2 genotyping identified 27 and 33 recrudescences by use of single‐ and consecutive‐day sampling, respectively; in subsequent msp1 genotyping, 17 and 21 of these episodes, respectively, were still classified as recrudescences; these results indicate a similar sensitivity of the standard single‐day PCR protocol—that is, 82% (27/33) and 81% (17/21), in both genotyping steps. Interpretation of PCR‐adjusted results will significantly depend on methodology.

Received 21 March 2006; accepted 2 October 2006; electronically published 5 January 2007.

Reprints or correspondence: Dr. Andreas Mårtensson, Infectious Diseases Unit, Dept. of Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden ().

Cited by

Jonathan J. Juliano, Frederic Ariey, Rithy Sem, Noppadon Tangpukdee, Srivicha Krudsood, Carol Olson, Sornchai Looareesuwan, William O. Rogers, Chansuda Wongsrichanalai, and Steven R. Meshnick. Misclassification of Drug Failure in Plasmodium falciparum Clinical Trials in Southeast Asia. The Journal of Infectious Diseases 0:0, 000-000
Abstract-Full Text-PDF Version (140 kB)
Samuel L. Nsobya, Moses Kiggundu, Moses Joloba, Grant Dorsey, Philip J. Rosenthal. (2008) Complexity of Plasmodium falciparum Clinical Samples from Uganda during Short‐Term Culture. The Journal of Infectious Diseases 198:10, 1554-1557
Online publication date: 15-Nov-2008.
Abstract-Full Text-PDF Version (146 kB)

  • Potential conflicts of interest: none reported.

    Financial support: Swedish Development Cooperation Agency–Department for Research Cooperation (grants SWE 2005‐017 and SWE 2005‐004596); Research and Development Unit, Sörmland Count Council, Sweden (project grant 82090); Goljes Foundation (project grants 248/04 and 317/05).

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