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1 February 2007

Volume 195, Number 3
The Journal of Infectious Diseases 2007;195:410–415
© 2007 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2007/19503-0015$15.00
DOI: 10.1086/510623
BRIEF REPORT

Reconstitution of Herpes Simplex Virus–Specific T Cell Immunity in HIV‐Infected Patients Receiving Highly Active Antiretroviral Therapy

Meghna Ramaswamy,1

Anele Waters,5

Colette Smith,3

Emma Hainsworth,1

Gareth Hardy,4

Margaret Johnson,2

Jonathan Ainsworth,5

Andrew Phillips,3 and

Anna Maria Geretti1

1Department of Virology and 2Department of HIV Medicine, Royal Free Hospital and Royal Free and University College Medical School, 3Department of Primary Care and Population Sciences and 4Department of Immunology, Royal Free and University College Medical School, and 5Department of HIV Medicine, North Middlesex University Hospital, London, United Kingdom

Production of herpes simplex virus (HSV)–specific interferon‐γ by peripheral‐blood mononuclear cells (PBMCs) of HSV‐seropositive healthy donors and human immunodeficiency virus–infected persons was determined by use of ELISPOT. The mean ± SD number of spot‐forming cells/106 PBMCs was 314 ± 74 in 11 healthy donors, 360 ± 69 in 3 long‐term nonprogressors (LTNPs), 186 ± 52 in 9 newly diagnosed patients, and 181 ± 59 in 33 patients who were receiving highly active antiretroviral therapy (HAART) for a median period of 30 months (range, 1–109 months). In 9 patients monitored prospectively while receiving virologically and immunologically successful first‐line HAART, the number of spot‐forming cells increased by 5.6/month (95% confidence interval, 1.2–9.9 [ ]) and 21.3/100 CD4 cells/mm3 gained (95% confidence interval, 13.8–28.7 [ ]). Responses were correlated with LTNP status and CD4 cell count.

Received 1 June 2006; accepted 20 September 2006; electronically published 20 December 2006.

Reprints or correspondence: Dr. Anna Maria Geretti, Dept. of Virology, Royal Free Hospital and Royal Free and University College Medical School, Rowland Hill St., London NW3 2PF, United Kingdom ().

Cited by

M Estee Torok, Andrew Kambugu, Edwina Wright. (2008) Immune reconstitution disease of the central nervous system. Current Opinion in HIV and AIDS 3:4, 438-445
Online publication date: 1-Aug-2008.
CrossRef
Meghna Ramaswamy, Anna Maria Geretti. (2007) Interactions and management issues in HSV and HIV coinfection. Expert Review of Anti-infective Therapy 5:2, 231-243
Online publication date: 1-May-2007.
CrossRef

  • Presented in part: 13th Conference on Retroviruses and Opportunistic Infections, Denver, Colorado, 5–8 February 2006 (abstract 786).

    Potential conflicts of interest: none reported.

    Financial support: Royal Free and University College Medical School (London) Ph.D. training fellowship (to M.R.).

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