All Journals > The Journal of Infectious Diseases > 15 January 2007 > Antibiotic Effects on Production of S. aureus Toxin

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

15 January 2007

Volume 195, Number 2
The Journal of Infectious Diseases 2007;195:202–211
0022-1899/2007/19502-0008$15.00
DOI: 10.1086/510396
MAJOR ARTICLE

Impact of Antibiotics on Expression of Virulence‐Associated Exotoxin Genes in Methicillin‐Sensitive and Methicillin‐Resistant Staphylococcus aureus

Dennis L. Stevens,1,2

Yongsheng Ma,1

Daniel B. Salmi,1

Eric McIndoo,1

Randi J. Wallace,1 and

Amy E. Bryant1

1Veterans Affairs Medical Center, Boise, Idaho; 2University of Washington School of Medicine, Seattle

Extracellular protein toxins contribute to the pathogenesis of a wide variety of Staphylococcus aureus infections. The present study investigated the effects that cell‐wall active antibiotics and protein‐synthesis inhibitors have on transcription and translation of genes for Panton‐Valentine leukocidin, alpha‐hemolysin, and toxic‐shock syndrome toxin 1, in both methicillin‐sensitive and methicillin‐resistant S. aureus. Subinhibitory concentrations of nafcillin induced and prolonged mRNA for Panton‐Valentine leukocidin, alpha‐toxin, and toxic‐shock syndrome toxin 1 and increased toxin production. In contrast, clindamycin and linezolid markedly suppressed translation, but not transcription, of toxin genes. These results suggest (1) that protein‐synthesis inhibition is an important consideration in the selection of antimicrobial agents to treat serious infections caused by toxin‐producing gram‐positive pathogens and (2) that, by inducing and enhancing toxin production, inadvertent use of beta‐lactam antibiotics to treat methicillin‐resistant S. aureus infections may contribute to worse outcomes.

Received 18 February 2006; accepted 6 September 2006; electronically published 18 December 2006.

Reprints or correspondence: Dr. Dennis L. Stevens, Infectious Diseases Section, Veterans Affairs Medical Center, 500 W. Fort St. (Bldg. 45), Boise, ID 83702 ().

Cited by

IAN A. JENKINS, MICHAEL SAUNDERS. (2009) Infections of the airway. Pediatric Anesthesia 19, 118-130
Online publication date: 1-Aug-2009.
CrossRef
N. Abdel-Haq, H. Al-Tatari, P. Chearskul, H. Salimnia, B. I. Asmar, M. R. Fairfax, M. Amjad. (2009) Methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized children: correlation of molecular analysis with clinical presentation and antibiotic susceptibility testing (ABST) results. European Journal of Clinical Microbiology & Infectious Diseases 28:5, 547-551
Online publication date: 1-Jun-2009.
CrossRef
F. K. Gould, R. Brindle, P. R. Chadwick, A. P. Fraise, S. Hill, D. Nathwani, G. L. Ridgway, M. J. Spry, R. E. Warren, . (2009) Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the United Kingdom. Journal of Antimicrobial Chemotherapy 63:5, 849-861
Online publication date: 5-Apr-2009.
CrossRef
Mukesh Patel. (2009) Community-Associated Meticillin-Resistant Staphylococcus aureus Infections. Drugs 69:6, 693-716
Online publication date: 1-Feb-2009.
CrossRef
A.K. Shumaker, J.C. Angus, K.S. Coyner, D.G. Loeffler, S.C. Rankin, T.P. Lewis. (2008) Microbiological and histopathological features of canine acral lick dermatitis. Veterinary Dermatology 19:5, 288-298
Online publication date: 1-Nov-2008.
CrossRef
Lena M. Napolitano. (2008) Early Appropriate Parenteral Antimicrobial Treatment of Complicated Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. Surgical Infections 9:s1, s17-s27
Online publication date: 1-Nov-2008.
CrossRef
Blanca E. Gonzalez, Sheldon L. Kaplan. (2008) Severe Staphylococcal Infections in Children. Pediatric Annals 37:10, 686-693
Online publication date: 1-Nov-2008.
CrossRef
Tina Q Tan, Ram Yogev. (2008) Clinical pharmacology of linezolid: an oxazolidinone antimicrobial agent. Expert Review of Clinical Pharmacology 1:4, 479-489
Online publication date: 1-Aug-2008.
CrossRef
Edina Avdic, Sara E Cosgrove. (2008) Management and control strategies for community-associated methicillin-resistant Staphylococcus aureus. Expert Opinion on Pharmacotherapy 9:9, 1463-1479
Online publication date: 1-Jul-2008.
CrossRef
Martin E. Stryjewski and Henry F. Chambers. (2008) Skin and Soft‐Tissue Infections Caused by Community‐Acquired Methicillin‐Resistant Staphylococcus aureus. Clinical Infectious Diseases 46:s5, S368-S377
Online publication date: 1-Jun-2008.
Ethan Rubinstein, Marin H. Kollef, and Dilip Nathwani. (2008) Pneumonia Caused by Methicillin‐Resistant Staphylococcus aureus. Clinical Infectious Diseases 46:s5, S378-S385
Online publication date: 1-Jun-2008.
Ellen K. Silbergeld, Jay Graham, Lance B. Price. (2008) Industrial Food Animal Production, Antimicrobial Resistance, and Human Health. Annual Review of Public Health 29:1, 151-169
Online publication date: 1-May-2008.
CrossRef
O. Dumitrescu, C. Badiou, M. Bes, M.-E. Reverdy, F. Vandenesch, J. Etienne, G. Lina. (2008) Effect of antibiotics, alone and in combination, on Panton–Valentine leukocidin production by a Staphylococcus aureus reference strain. Clinical Microbiology and Infection 14:4, 384-388
Online publication date: 1-May-2008.
CrossRef
Robert C. Moellering, Jr.. (2008) Current Treatment Options for Community‐Acquired Methicillin‐Resistant Staphylococcus aureus Infection. Clinical Infectious Diseases 46:7, 1032-1037
Online publication date: 1-Apr-2008.
Louis B. Rice, John G. Bartlett, Donald E. Craven, Dennis L. Stevens, Robert C. Moellering, George M. Eliopoulos. (2008) Emerging Treatments for Resistant Bacterial Infections and Pathogen-Focused Therapy. Infectious Diseases in Clinical Practice 16:Suppl. 1, S1-S20
Online publication date: 1-Apr-2008.
CrossRef
Michael W Ellis. (2008) Is antimicrobial therapy needed to manage uncomplicated skin and soft-tissue abscesses?. Expert Review of Anti-infective Therapy 6:1, 9-13
Online publication date: 1-Mar-2008.
CrossRef
Stan Deresinski, Section Editor. (2008) In the Literature. Clinical Infectious Diseases 46:4, v-vi
Online publication date: 15-Feb-2008.
N. Jung, C. Lehmann, M. Hellmann, H. Seifert, M. M. Valter, M. Hallek, G. Fätkenheuer, M. Kochanek. (2008) Necrotizing Pneumonia Caused by Panton-Valentine Leucocidin-Producing Staphylococcus aureus Originating from a Bartholin's Abscess. Infectious Diseases in Obstetrics & Gynecology 2008, 1-6
Online publication date: 1-Feb-2008.
CrossRef
Cindy A Loffler, Conan MacDougall. (2008) Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections. Expert Review of Anti-infective Therapy 5:6, 961-981
Online publication date: 1-Jan-2008.
CrossRef
Stephanie M. Hamilton, Amy E. Bryant, Karen C. Carroll, Vivian Lockary, Yongsheng Ma, Eric McIndoo, Loren G. Miller, Francoise Perdreau‐Remington, John Pullman, George F. Risi, Daniel B. Salmi, and Dennis L. Stevens. (2007) In Vitro Production of Panton‐Valentine Leukocidin among Strains of Methicillin‐Resistant Staphylococcus aureus Causing Diverse Infections. Clinical Infectious Diseases 45:12, 1550-1558
Online publication date: 15-Dec-2007.
R. Plummer, J. Bodkin, T.W. Yau, D. Power, N. Pantarat, T.J. Larkin, D. Szekely, W.A. Bubb, T.C. Sorrell, P.W. Kuchel. (2007) ModellingStaphylococcus aureus–induced septicemia using NMR. Magnetic Resonance in Medicine 58:4, 656-665
Online publication date: 1-Nov-2007.
CrossRef
Marin H. Kollef. (2007) Limitations of Vancomycin in the Management of Resistant Staphylococcal Infections. Clinical Infectious Diseases 45:s3, S191-S195
Online publication date: 15-Sep-2007.
Scott T. Micek. (2007) Alternatives to Vancomycin for the Treatment of Methicillin‐Resistant Staphylococcus aureus Infections. Clinical Infectious Diseases 45:s3, S184-S190
Online publication date: 15-Sep-2007.
Brooks Gainer. (2007) Snapshot for May 2007. Infectious Diseases in Clinical Practice 15:3, 143
Online publication date: 1-Jun-2007.
CrossRef
  • Potential conflicts of interest: D.L.S. has received research‐grant funding from Amgen, Cubist, Roche, Pfizer, and Wyeth Pharmaceutical.

    Financial support: Medical Research Service, Department of Veterans Administration; Pfizer Pharmaceuticals.

Close Popup