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1 January 2007

Volume 44, Number 1
Clinical Infectious Diseases 2007;44:141–144
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4401-0025$15.00
DOI: 10.1086/510078
HIV/AIDS BRIEF REPORT

Nevirapine Levels after Discontinuation of Rifampicin Therapy and 60‐Week Efficacy of Nevirapine‐Based Antiretroviral Therapy in HIV‐Infected Patients with Tuberculosis

Weerawat Manosuthi,1

Kiat Ruxrungtham,2

Sirirat Likanonsakul,1

Wisit Prasithsirikul,1

Yaowarat Inthong,1

Thanongsri Phoorisri,1 and

Somnuek Sungkanuparph3

1Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, and 2The HIV Netherlands‐Australia‐Thailand Research Collaboration, Thai Red Cross AIDS Research Centre and Chulalongkorn University, and 3Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Seventy patients with human immunodeficiency virus (HIV) and tuberculosis coinfection who initiated nevirapine‐based antiretroviral therapy and had trough nevirapine levels determined while receiving rifampicin were enrolled in a study. After discontinuation of rifampicin therapy, mean nevirapine levels (± standard deviation) increased from mg/L to mg/L ( ), but no nevirapine‐related adverse events occurred. There was no statistically significant difference in 60‐week antiviral efficacy between these patients and patients receiving nevirapine‐based antiretroviral therapy alone ( ).

Received 21 July 2006; accepted 1 September 2006; electronically published 21 November 2006.

Reprints or correspondence: Dr. Weerawat Manosuthi, Dept. of Medicine, Bamrasnaradura Infectious Diseases Institute, Tiwanon Rd., Nonthaburi, 11000, Thailand ().

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Online publication date: 15-Jun-2009.
Abstract-Full Text-PDF Version (308 kB)
Doaa Elsherbiny, Karen Cohen, Britt Jansson, Peter Smith, Helen McIlleron, Ulrika S. H. Simonsson. (2009) Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients. European Journal of Clinical Pharmacology 65:1, 71-80
Online publication date: 1-Feb-2009.
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