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1 January 2007

Volume 44, Number 1
Clinical Infectious Diseases 2007;44:135–138
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4401-0023$15.00
DOI: 10.1086/510072
HIV/AIDS BRIEF REPORT

Can Routine Clinical Markers Be Used Longitudinally to Monitor Antiretroviral Therapy Success in Resource‐Limited Settings?

Shashwatee Bagchi,1

Mirjam C. Kempf,2

Andrew O. Westfall,3

Anastasiya Maherya,1

James Willig,1 and

Michael S. Saag1

1Divisions of Geographic Medicine and Infectious Disease and Center for AIDS Research, Department of Medicine, and Departments of 2Epidemiology and 3Biostatistics, School of Public Health, University of Alabama at Birmingham

Although routine clinical markers are used routinely to determine the stage of human immunodeficiency virus (HIV) disease, their use in monitoring response to antiretroviral therapy is poorly defined. Selected clinical markers were evaluated for their ability to predict first‐line antiretroviral therapy success. No clinically meaningful variables were identified that predicted virologic or immunological success, implying that the CD4+ cell count and HIV type 1 RNA level data are required for optimal management of antiretroviral therapy.

Received 2 June 2006; accepted 27 August 2006; electronically published 28 November 2006.

  • (See the article by Calmy et al. on pages 128–34 and the editorial commentary by Schooley on pages 139–40)

Reprints or correspondence: Dr. Michael Saag, University of Alabama at Birmingham, Center for AIDS Research, 845 19th St. S., BBRB 256, Birmingham, AL 35294 ().

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