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1 January 2007

Volume 44, Number 1
Clinical Infectious Diseases 2007;44:69–73
This article is in the public domain, and no copyright is claimed.
1058-4838/2007/4401-0012
DOI: 10.1086/509928
BRIEF REPORT

Low Sensitivity of a Whole‐Blood Interferon‐γ Release Assay for Detection of Active Tuberculosis

Puneet K. Dewan,1

Jennifer Grinsdale,2 and

L. Masae Kawamura2

1International Research and Programs Branch, Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia; and 2San Francisco Department of Public Health, San Francisco, California

The sensitivity of an interferon‐γ assay (Quantiferon‐TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty‐seven subjects had culture‐confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had positive results using the QuantiFERON‐TB Gold assay. The 64% sensitivity suggests that the QuantiFERON‐TB Gold assay should not be used alone to exclude active tuberculosis.

Received 19 July 2006; accepted 23 August 2006; electronically published 28 November 2006.

Reprints or correspondence: Dr. Puneet K. Dewan, International Research and Programs Branch, Div. of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS E10, Atlanta, GA 30333 ().

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