All Journals > Clinical Infectious Diseases > 1 December 2006 > HIV/AIDS

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 December 2006

Volume 43, Number 11
Clinical Infectious Diseases 2006;43:1482–1489
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2006/4311-0019$15.00
DOI: 10.1086/509575
HIV/AIDS MAJOR ARTICLE

Risk of Cardiovascular Disease in a Cohort of HIV‐Infected Adults: A Study Using Carotid Intima‐Media Thickness and Coronary Artery Calcium Score

Alexandra Mangili,1,3

Jul Gerrior,3

Alice M. Tang,3

Daniel H. O’Leary,2

Joseph K. Polak,2

Ernst J. Schaefer,1

Sherwood L. Gorbach,1,3 and

Christine A. Wanke1,3

Departments of 1Medicine and 2Radiology, Tufts‐New England Medical Center, and 3Nutrition Infection Unit, Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, Massachusetts

Background.There is concern that human immunodeficiency virus (HIV) infection and the use of highly active antiretroviral therapy lead to accelerated atherosclerosis and increased risk of cardiovascular disease. We measured 2 surrogate markers of subclinical atherosclerosis, carotid intima‐media thickness (c‐IMT) and coronary artery calcium (CAC) scores, in HIV‐infected adults.

Methods.A cross‐sectional analysis of 242 men and 85 women with HIV infection was used. Carotid ultrasonography and coronary computed tomography were performed, and their associations with cardiovascular risk factors were examined.

Results.Among men, the mean (± standard deviation [SD]) common c‐IMT was mm, the mean (±SD) internal c‐IMT was mm, and 136 patients (56.1%) had detectable CAC. Among women, the mean (±SD) common c‐IMT was mm, the mean (±SD) internal c‐IMT was mm, and 40 patients (47.1%) had detectable CAC. Neither the c‐IMT nor the CAC score differed by antiretroviral therapy class or individual medications for either sex. For men, age and waist circumference independently predicted common c‐IMT; age, systolic blood pressure, and high‐sensitivity C‐reactive protein level independently predicted internal c‐IMT; and age, apolipoprotein B level, and high‐sensitivity C‐reactive protein level independently predicted CAC score. For women, age and body mass index independently predicted common c‐IMT; age independently predicted internal c‐IMT; and age and glucose level independently predicted CAC score.

Conclusions.Our participants had more abnormal surrogate markers than expected at a relatively young age, but those were not associated with use of highly active antiretroviral therapy or protease inhibitors. At present, the positive associations were primarily with traditional and novel cardiovascular risk factors. Some HIV‐specific (not treatment‐specific) factors were observed; they may become more evident with prolonged HIV infection and treatment.

Received 2 May 2006; accepted 10 August 2006; electronically published 31 October 2006.

Reprints or correspondence: Dr. Alexandra Mangili, Tufts University School of Medicine, Nutrition/Infection Unit, Jaharis 275, 150 Harrison Ave., Boston, MA 02111 ().

Cited by

Jennifer H Yearley, Dongling Xia, Christine B Pearson, Angela Carville, Richard P Shannon, Keith G Mansfield. (2009) Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet. Laboratory Investigation 89:6, 657-667
Online publication date: 1-Jul-2009.
CrossRef
Anne-Mette Lebech, Ulrik Sloth Kristoffersen, Niels Wiinberg, Kristian Kofoed, Ove Andersen, Birger Hesse, Claus Leth Petersen, Jan Gerstoft, Andreas Kjær. (2008) Coronary and peripheral endothelial function in HIV patients studied with positron emission tomography and flow-mediated dilation: relation to hypercholesterolemia. European Journal of Nuclear Medicine and Molecular Imaging 35:11, 2049-2058
Online publication date: 1-Dec-2008.
CrossRef
Lawrence A Kingsley, Juliana Cuervo-Rojas, Alvaro Muñoz, Frank J Palella, Wendy Post, Mallory D Witt, Matthew Budoff, Lewis Kuller. (2008) Subclinical coronary atherosclerosis, HIV infection and antiretroviral therapy: Multicenter AIDS Cohort Study. AIDS 22:13, 1589-1599
Online publication date: 1-Sep-2008.
CrossRef
Robert C Kaplan, Lawrence A Kingsley, Stephen J Gange, Lorie Benning, Lisa P Jacobson, Jason Lazar, Kathryn Anastos, Phyllis C Tien, A Richey Sharrett, Howard N Hodis. (2008) Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS 22:13, 1615-1624
Online publication date: 1-Sep-2008.
CrossRef
Robert Murphy, Dominique Costagliola. (2008) Increased cardiovascular risk in HIV infection: drugs, virus and immunity. AIDS 22:13, 1625-1627
Online publication date: 1-Sep-2008.
CrossRef
Nina Friis-Møller, Marek Smieja, Daniel Klein. (2008) Antiretroviral therapy as a cardiovascular disease risk factor: fact or fiction? A review of clinical and surrogate outcome studies. Current Opinion in HIV and AIDS 3:3, 220-225
Online publication date: 1-Jun-2008.
CrossRef
Daniel Periard, Matthias Cavassini, Patrick Taffé, Melanie Chevalley, Laurence Senn, Caroline Chapuis‐Taillard, Serge de Vallière, Daniel Hayoz, and Philip E. Tarr, for the Swiss HIV Cohort Study. (2008) High Prevalence of Peripheral Arterial Disease in HIV‐Infected Persons. Clinical Infectious Diseases 46:5, 761-767
Online publication date: 1-Mar-2008.
Abstract-Full Text-PDF Version (282 kB)
Caroline A Sabin. (2008) Cardiovascular risk and choice of HIV drug regimen. Future HIV Therapy 2:1, 83-92
Online publication date: 1-Feb-2008.
CrossRef
Candice M Thomas, Eric J Smart. (2007) How HIV protease inhibitors promote atherosclerotic lesion formation. Current Opinion in Lipidology 18:5, 561-565
Online publication date: 1-Nov-2007.
CrossRef
Judith S Currier, Michelle A Kendall, W Keith Henry, Beverly Alston-Smith, Francesca J Torriani, Pablo Tebas, Yanjie Li, Howard N Hodis. (2007) Progression of carotid artery intima???media thickening in HIV-infected and uninfected adults. AIDS 21:9, 1137???1145
Online publication date: 1-Jun-2007.
CrossRef
Alexandra Mangili, Denise L. Jacobson, Jul Gerrior, Joseph F. Polak, Sherwood L. Gorbach, and Christine A. Wanke. (2007) Metabolic Syndrome and Subclinical Atherosclerosis in Patients Infected with HIV. Clinical Infectious Diseases 44:10, 1368-1374
Online publication date: 15-May-2007.
Abstract-Full Text-PDF Version (244 kB)
Alexandra Mangili, Christine A Wanke. (2007) Dyslipidemia in HIV infection. Future Lipidology 1:6, 719-728
Online publication date: 1-Jan-2007.
CrossRef
Back to Top
Close Popup