All Journals > Clinical Infectious Diseases > 1 October 2006 > XDR TB in Iran

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 October 2006

Volume 43, Number 7
Clinical Infectious Diseases 2006;43:841–847
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2006/4307-0007$15.00
DOI: 10.1086/507542
MAJOR ARTICLE

Extensively Drug‐Resistant Tuberculosis: 2 Years of Surveillance in Iran

Mohamad Reza Masjedi,1

Parissa Farnia,1

Setara Sorooch,1

Majid Valiollah Pooramiri,1

Seyed Davood Mansoori,1

Abolhasan Zia Zarifi,1

Ali AkbarVelayati,1 and

Sven Hoffner2

1National Research Institute of Tuberculosis and Lung Diseases, Tehran, Iran; and 2Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solana, Sweden

Background.Extensively drug‐resistant (XDR) tuberculosis (TB) is a cause of concern, because it renders patients untreatable with available drugs. In this study, we documented the existence and transmission of XDR TB among patients with multidrug‐resistant TB. These patients were referred to the National Research Institute of Tuberculosis and Lung Diseases (Tehran, Iran) for treatment and diagnosis from 2003 to 2005.

Methods.The sputum specimens from a total of 2030 patients with TB were digested, examined microscopically for acid‐fast bacilli, and inoculated into Löwenstein‐Jensen slants by standard procedures. Testing of susceptibility to first‐line drugs was performed for 1284 Mycobacterium tuberculosis isolates. Subsequently, the strains that were identified as multidrug‐resistant M. tuberculosis (113 isolates) were subjected to susceptibility testing for second‐line drugs. Spoligotyping and restriction fragment–length polymorphism were performed for strains that were identified as XDR M. tuberculosis.

Results.A total of 12 (10.9%) of 113 multidrug‐resistant M. tuberculosis strains were resistant to all 8 second‐line drugs tested and, therefore, were denoted as XDR M. tuberculosis. Retrospective analysis of the cases of XDR TB showed that all of them belonged to 1 of 2 epidemiological clusters, either a single‐family cluster (4 cases) or a cluster of close contacts (8 cases). The strains were identified as belonging to the M. tuberculosis superfamilies Haarlem 1 and East African Indian 3.

Conclusions.The emergence of XDR TB cases in Iran highlights the need to reinforce the Iranian TB policy with regard to control and detection strategies.

Received 26 April 2006; accepted 14 June 2006; electronically published 21 August 2006.

Reprints or correspondence: Dr. P. Farnia, Iranian National Reference TB Laboratory, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), WHO Collaborating Centre of Tuberculosis, Shaheed Bahonar Ave., Darabad, Tehran, 19556, P.O. 19575/154, Iran ().

Cited by

Jerrold J. Ellner. (2009) The Emergence of Extensively Drug-Resistant Tuberculosis: A Global Health Crisis Requiring New Interventions: Part I: The Origins and Nature of the Problem. Clinical and Translational Science 1:3, 249-254
Online publication date: 1-Jan-2009.
CrossRef
Amita Jain, Pratima Dixit. (2008) Multidrug resistant to extensively drug resistant tuberculosis: What is next?. Journal of Biosciences 33:4, 605-616
Online publication date: 1-Dec-2008.
CrossRef
Ritu Banerjee, Gisela F Schecter, Jennifer Flood, Travis C Porco. (2008) Extensively drug-resistant tuberculosis: new strains, new challenges. Expert Review of Anti-infective Therapy 6:5, 713-724
Online publication date: 1-Nov-2008.
CrossRef
Ritu Banerjee, Jennifer Allen, Janice Westenhouse, Peter Oh, William Elms, Ed Desmond, Annette Nitta, Sarah Royce, and Jennifer Flood. (2008) Extensively Drug‐Resistant Tuberculosis in California, 1993–2006. Clinical Infectious Diseases 47:4, 450-457
Online publication date: 15-Aug-2008.
Abstract-Full Text-PDF Version (331 kB)
Amita Jain, Rajesh Mondal. (2008) Extensively drug-resistant tuberculosis: current challenges and threats. FEMS Immunology & Medical Microbiology 53:2, 145-150
Online publication date: 1-Aug-2008.
CrossRef
João Perdigão, Rita Macedo, Inês João, Elisabete Fernandes, Laura Brum, Isabel Portugal. (2008) Multidrug-Resistant Tuberculosis in Lisbon, Portugal: A Molecular Epidemiological Perspective. Microbial Drug Resistance 14:2, 133-143
Online publication date: 1-Jul-2008.
CrossRef
Christie Y. Jeon, Soo Hee Hwang, Jin Hong Min, D. Rebecca Prevots, Lisa C. Goldfeder, Hyeyoung Lee, Seok Yong Eum, Doo Soo Jeon, Hyung Seok Kang, Jin Hee Kim, Byoung Ju Kim, Dae Yeon Kim, Steven M. Holland, Seung Kyu Park, Sang Nae Cho, Clifton E. Barry, 3rd, and Laura E. Via. (2008) Extensively Drug‐Resistant Tuberculosis in South Korea: Risk Factors and Treatment Outcomes among Patients at a Tertiary Referral Hospital. Clinical Infectious Diseases 46:1, 42-49
Online publication date: 1-Jan-2008.
Abstract-Full Text-PDF Version (393 kB)
Wing Wai YEW, Chi Chiu LEUNG. (2007) Management of multidrug-resistant tuberculosis: Update 2007. Respirology 0:0, 071031182005003-???
Online publication date: 1-Dec-2007.
CrossRef
Sarman Singh, Manimuthu Mani Sankar, Krishnamoorthy Gopinath. (2007) High rate of extensively drug-resistant tuberculosis in Indian AIDS patients. AIDS 21:17, 2345-2347
Online publication date: 1-Dec-2007.
CrossRef
Alberto Matteelli, Giovanni Battista Migliori, Daniela Cirillo, Rosella Centis, Enrico Girard, Mario Raviglione. (2007) Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control. Expert Review of Anti-infective Therapy 5:5, 857-871
Online publication date: 1-Nov-2007.
CrossRef
N. Scherr, S. Honnappa, G. Kunz, P. Mueller, R. Jayachandran, F. Winkler, J. Pieters, M. O. Steinmetz. (2007) From the Cover: Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences 104:29, 12151-12156
Online publication date: 17-Aug-2007.
CrossRef
Charles D. Wells, J. Peter Cegielski, Lisa J. Nelson, Kayla F. Laserson, Timothy H. Holtz, Alyssa Finlay, Kenneth G. Castro, and Karin Weyer. (2007) HIV Infection and Multidrug‐Resistant Tuberculosis—The Perfect Storm. The Journal of Infectious Diseases 196:s1, S86-S107
Online publication date: 1-Jul-2007.
Abstract-Full Text-PDF Version (554 kB)
Prasanta Raghab Mohapatra. (2007) The Threat of Extensively Drug‐Resistant Tuberculosis. Clinical Infectious Diseases 44:6, 888-889
Online publication date: 15-Mar-2007.
Citation-Full Text-PDF Version (319 kB)
J. C. Palomino, A. Martin, F. Portaels. (2007) Rapid drug resistance detection in Mycobacterium tuberculosis: a review of colourimetric methods. Clinical Microbiology and Infection 0:0, 070322060958006
CrossRef
Back to Top
Close Popup