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1 October 2006

Volume 194, Number 7
The Journal of Infectious Diseases 2006;194:912–916
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19407-0007$15.00
DOI: 10.1086/507308
BRIEF REPORT

Repeated Intravaginal Inoculation with Cell‐Associated Simian Immunodeficiency Virus Results in Persistent Infection of Nonhuman Primates

Masahiko Kaizu,2

Andrea M. Weiler,2

Kim L. Weisgrau,1

Kathleen A. Vielhuber,2

Gemma May,1

Shari M. Piaskowski,2

Jessica Furlott,2

Nicholas J. Maness,1

Thomas C. Friedrich,1

John T. Loffredo,2

Amy Usborne,3 and

Eva G. Rakasz1,2

1Immunogenetics and Virology Unit, 2AIDS Vaccine Research Laboratory, and 3Clinical Pathology Unit, Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison

The goal of the present study was to develop a nonhuman primate model of intravaginal human immunodeficiency virus (HIV) transmission with cell‐associated virus. Reproductively mature, cycling cynomolgus macaques with or without chemically induced, transient ulcers of the lower female reproductive tract repeatedly received challenge with a variable amount of in vitro simian immunodeficiency virus mac239–infected peripheral blood mononuclear cells. Persistent viremia was established with surprisingly few infectious lymphocytes containing physiologically relevant quantities of cell‐associated virus. This model will be indispensable for the testing of vaccines and topical agents that are aimed toward the prevention of heterosexual transmission of HIV.

Received 13 February 2006; accepted 17 April 2006; electronically published 29 August 2006.

Reprints or correspondence: Dr. Eva G. Rakasz, AIDS Vaccine Laboratory, WNPRC, 555 Science Dr., Madison, WI 53711 ().

Cited by

Joseph A Politch, Kenneth H Mayer, Deborah J Anderson. (2009) Depletion of CD4+ T Cells in Semen During HIV Infection and Their Restoration Following Antiretroviral Therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes 50:3, 283-289
Online publication date: 1-Apr-2009.
CrossRef
Jay A Levy. (2009) HIV pathogenesis: 25 years of progress and persistent challenges. AIDS 23:2, 147-160
Online publication date: 1-Feb-2009.
CrossRef
Florian Hladik, M. Juliana McElrath. (2008) Setting the stage: host invasion by HIV. Nature Reviews Immunology 8:6, 447-457
Online publication date: 1-Jul-2008.
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Robert M. Grant and Mark A. Wainberg. (2006) Chemoprophylaxis of HIV Infection: Moving Forward with Caution. The Journal of Infectious Diseases 194:7, 874-876
Online publication date: 1-Oct-2006.
Citation-Full Text-PDF Version (57 kB)

  • Financial support: Wisconsin National Primate Research Center (base grant P51 RR00167).

    Potential conflicts of interest: none reported.

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