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1 October 2006

Volume 194, Number 7
The Journal of Infectious Diseases 2006;194:975–983
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19407-0015$15.00
DOI: 10.1086/506950
MAJOR ARTICLE

Modulation of the Triggering Receptor Expressed on Myeloid Cells–1 Pathway during Pneumonia in Rats

Sébastien Gibot,1,2

Corentine Alauzet,3

Frédéric Massin,4

Nassira Sennoune,2

Gilbert C. Faure,4

Marie‐Christine Béné,4

Alain Lozniewski,3

Pierre‐Edouard Bollaert,1,2 and

Bruno Lévy1,2

1Service de Réanimation Médicale, Hôpital Central, and 2Laboratoire de Physiologie Expérimentale (Groupe Choc), 3Laboratoire de Bactériologie, UMR CNRS 7565, and 4Laboratoire d’Immunologie, Faculté de Médecine, Nancy Université, Nancy, France

Background.Triggering receptor expressed on myeloid cells–1 (TREM‐1) is a cell‐surface molecule that has been identified on both human and murine polymorphonuclear neutrophils and mature monocytes. The activation of TREM‐1 in the presence of microbial components amplifies the inflammatory response and may be responsible for the hyperresponsiveness observed during the initial stage of sepsis. The aim of the present study was to investigate the effect of the modulation of the TREM‐1 pathway during experimental pneumonia in rats.

Methods.Adult male Wistar rats were intratracheally inoculated with Pseudomonas aeruginosa (PAO1 strain) and randomly treated or not treated with an analogue synthetic peptide derived from the extracellular moiety of TREM‐1 (LP17).

Results.P. aeruginosa induced a severe pneumonia associated with signs of severe sepsis within the first 24 h. In septic rats, LP17 improved hemodynamic status, attenuated the development of lactic acidosis and hypoxemia, modulated lung and systemic inflammatory responses and coagulation activation, reduced lung histological damage, and improved survival.

Conclusions.The modulation of the TREM‐1 pathway by the use of such synthetic peptides as LP17 appears beneficial during P. aeruginosa pneumonia in rats in attenuating lung and systemic inflammatory responses.

Received 13 March 2006; accepted 9 May 2006; electronically published 29 August 2006.

Reprints or correspondence: Dr. Sébastien Gibot, Service de Réanimation Médicale, 29 bld. du Maréchal de Lattre de Tassigny, Hôpital Central, 54035 Nancy, France ().

Cited by

Sébastien Gibot, Frédéric Massin, Corentine Alauzet, Chantal Montemont, Alain Lozniewski, Pierre-Edouard Bollaert, Bruno Levy. (2008) Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats. Critical Care Medicine 36:2, 504-510
Online publication date: 1-Mar-2008.
CrossRef
W. Joost Wiersinga, Cees van ‘t Veer, Catharina W. Wieland, Sebastien Gibot, Berend Hooibrink, Nicholas P. Day, Sharon J. Peacock, and Tom van der Poll. (2007) Expression Profile and Function of Triggering Receptor Expressed on Myeloid Cells–1 during Melioidosis. The Journal of Infectious Diseases 196:11, 1707-1716
Online publication date: 1-Dec-2007.
Abstract-Full Text-PDF Version (547 kB)
S.K. Tschöke, A. Oberholzer. (2007) Gentherapie zur Behandlung der akuten inflammatorischen Immunantwort. Der Orthopäde 36:3, 259-264
Online publication date: 1-Apr-2007.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Fondation Recherche Médicale; Association des Chefs de Service du Centre Hospitalier Universitaire de Nancy, France.

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