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15 September 2006

Volume 194, Number 6
The Journal of Infectious Diseases 2006;194:804–807
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19406-0012$15.00
DOI: 10.1086/506949
BRIEF REPORT

Further Development of a New Transgenic Mouse Test for the Evaluation of the Immunogenicity and Protective Properties of Inactivated Poliovirus Vaccine

Eugenia M. Dragunsky,1

Alexander P. Ivanov,1

Shinobu Abe,2

Svetlana G. Potapova,1,a

Joan C. Enterline,1

So Hashizume,2 and

Konstantin M. Chumakov1

1Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 2Poliomyelitis Research Institute, Tokyo, Japan

Recently, we developed and optimized a new method for the evaluation of the protective properties of serotype 2 inactivated poliovirus vaccines (IPV). The method is based on the immunization and subsequent challenge of transgenic (Tg) mice susceptible to poliovirus. We describe a similar method for the assessment of the protectiveness of serotype 1 IPV and demonstrate that experimental IPV produced from attenuated Sabin strain (sIPV) of serotype 1 poliovirus induced serum neutralizing antibodies, immunoglobulin (Ig) G, IgM, and salivary IgA at titers comparable to those induced by conventional IPV (cIPV) produced from the wild‐type Mahoney strain. In contrast to our previous results with serotype 2 sIPV, serotype 1 sIPV provided even better protection of Tg mice than cIPV against challenge with wild‐type Mahoney strain.

Received 8 February 2006; accepted 4 May 2006; electronically published 16 August 2006.

Reprints or correspondence: Eugenia M. Dragunsky, HFM‐470, NLRC/B‐121, 1401 Rockville Pike, MD 20852 ().

Cited by

Konstantin Chumakov and Ellie Ehrenfeld. (2008) Vaccines: New Generation of Inactivated Poliovirus Vaccines for Universal Immunization after Eradication of Poliomyelitis. Clinical Infectious Diseases 47:12, 1587-1592
Online publication date: 15-Dec-2008.
Abstract-Full Text-PDF Version (249 kB)

  • Presented in part: 7th International Symposium on Positive Strand RNA Viruses, San Francisco, 27 May–1 June 2004 (abstract P2‐B4).

    Potential conflicts of interest: none reported.

    Financial support: National Vaccine Program Office (grant 224‐95‐1247).

  • Present affiliation: National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

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