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15 September 2006

Volume 194, Number 6
The Journal of Infectious Diseases 2006;194:865–869
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19406-0020$15.00
DOI: 10.1086/506947
BRIEF REPORT

A Novel Copper–Hydrogen Peroxide Formulation for Prion Decontamination

Jérôme Solassol,1,2

Manuela Pastore,1

Carole Crozet,1

Véronique Perrier,4 and

Sylvain Lehmann1,3

1Institut de Génétique Humaine du Centre National de la Recherche Scientifique, UPR1142, 2Laboratoire de Biologie Cellulaire, Hôpital A. de Villeneuve, 3Laboratoire de Biochimie, Hôpital St. Eloi, and 4Vieillissement Cérébral et Pathogenèse des Maladies Neurodégénératives, U710 INSERM, Montpellier, France

With the appearance of variant Creutzfeldt‐Jakob disease (CJD) and the detection of infectious prions in the peripheral organs of persons with sporadic CJD, the development of decontamination methods that are compatible with medical equipment has become a major issue. Here, we show that a formulation of copper metal ions in combination with hydrogen peroxide dramatically reduces the level of prion protein (PrP)Sc (the scrapie isoform of PrP) present in homogenates of samples from prion‐infected brains, including brain samples from humans with CJD. An animal bioassay confirmed the reduction in prion infectivity, indicating that this novel Cu2+‐H2O2 formulation has great potential for prion decontamination.

Received 3 January 2006; accepted 8 May 2006; electronically published 10 August 2006.

Reprints or correspondence: J. Solassol, Institut de Génétique Humaine du CNRS, UPR1142, 141 rue de la Cardonille, 34396 Montpellier, France (); or, S. Lehmann, Institut de Génétique Humaine du CNRS, UPR1142, 141 rue de la Cardonille, 34396 Montpellier, France ().

Cited by

Kyozo SUYAMA, Miyako YOSHIOKA, Mitsugu AKAGAWA, Yuichi MURAYAMA, Hiroko HORII, Masuhiro TAKATA, Takashi YOKOYAMA, Shirou MOHRI. (2007) Assessment of Prion Inactivation by Fenton Reaction Using Protein Misfolding Cyclic Amplification and Bioassay. Bioscience, Biotechnology, and Biochemistry 71:8, 2069-2071
Online publication date: 1-Feb-2007.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Centre National de la Recherche Scientifique; GIS Prion.

    The results of the present study formed the basis of an international patent (no. 2870458; published 25 November 2005).

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