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1 September 2006

Volume 194, Number 5
The Journal of Infectious Diseases 2006;194:697–701
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19405-0023$15.00
DOI: 10.1086/506454
BRIEF REPORT

β‐Defensin Gene Expression during the Course of Experimental Tuberculosis Infection

Bruno Rivas‐Santiago,1,2

Eduardo Sada,1

Víctor Tsutsumi,2

Diana Aguilar‐León,3

Juan Leon Contreras,3 and

Rogelio Hernández‐Pando3

1Department of Microbiology Research, National Institute for Respiratory Diseases, 2Department of Experimental Pathology, Center for Research and Advanced Studies, National Polytechnic Institute, and 3Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico

The kinetics of gene expression and the cellular source of murine β‐defensin–3 (mBD3) and murine β‐defensin–4 (mBD4) were determined in mouse models of progressive pulmonary tuberculosis and latent infection induced by high or low infecting doses, respectively. During progressive disease, there was an initial rapid expression of both defensins by respiratory epithelial cells that correlated with temporary control of bacillary proliferation, but expression decreased during the later progressive phase of the disease. In latent infection, both defensins were expressed continuously, but they were suppressed after reactivation of the disease. Thus, mycobacterial infection induces the expression of mBD3 and mBD4, and both might participate in the control of mycobacterial growth.

Received 2 February 2006; accepted 20 April 2006; electronically published 28 July 2006.

Reprints or correspondence: Dr. Rogelio Hernández‐Pando, Experimental Pathology Section, Dept. of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, cp‐14000, Tlalpan, Mexico City, Mexico ( or ).

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  • Presented in part: 6th International Conference on the Pathogenesis of Mycobacterial Infections, Stockholm, 30 June–1 July 2005 (abstract 33).

    Potential conflicts of interest: none reported.

    Financial support: National Council of Science and Technology in Mexico (grant SEP‐2004‐C01‐47745); European Community (International Scientific Cooperation Projects grant ICA4‐CT‐2002‐10063).

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