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1 September 2006

Volume 43, Number 5
Clinical Infectious Diseases 2006;43:593–598
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2006/4305-0008$15.00
DOI: 10.1086/506356
MAJOR ARTICLE

Association of Polymorphisms of IGF1R and Genes in the Transforming Growth Factor–β/Bone Morphogenetic Protein Pathway with Bacteremia in Sickle Cell Anemia

Adeboye H. Adewoye,1

Vikki G. Nolan,1

Qianli Ma,1

Clinton Baldwin,2,3

Diego F. Wyszynski,1

John J. Farrell,1

Lindsay A. Farrer,1 and

Martin H. Steinberg1

Departments of 1Medicine and 2Pediatrics and 3Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts

Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF‐β/BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF‐β/BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a “bacteremia‐prone” phenotype.

Received 10 May 2006; accepted 18 May 2006; electronically published 14 July 2006.

Reprints or correspondence: Dr. Martin H. Steinberg, E248, Boston Medical Center, 88 E. Newton St., Boston, MA 02118 ().

Cited by

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Online publication date: 1-Jul-2009.
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Eizo Watanabe, Barbara Zehnbauer, Clifford S. Deutschman. (2009) Genetic variability and outcome in the critically ill: Avoiding SNP judgments*. Critical Care Medicine 37:1, 357-360
Online publication date: 1-Feb-2009.
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A. E. Ashley-Koch, L. Elliott, M. E. Kail, L. M. De Castro, J. Jonassaint, T. L. Jackson, J. Price, K. I. Ataga, M. C. Levesque, J. B. Weinberg, E. P. Orringer, A. Collins, J. M. Vance, M. J. Telen. (2008) Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood 111:12, 5721-5726
Online publication date: 15-Jul-2008.
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Julia E Brittain, Leslie V Parise. (2007) Cytokines and plasma factors in sickle cell disease. Current Opinion in Hematology 14:5, 438-443
Online publication date: 1-Oct-2007.
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  • Presented in part: 47th Annual Meeting of the American Society of Hematology, Atlanta, Georgia, 12 December 2005 (abstract 3170); Blood 2005;106:884a, and at the 29th Annual Meeting of the National Sickle Cell Disease Program, Memphis, Tennessee, 11 April 2006 (abstract 43).

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