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15 August 2006

Volume 43, Number 4
Clinical Infectious Diseases 2006;43:500–511
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2006/4304-0018$15.00
DOI: 10.1086/505979
INVITED ARTICLE HIV/AIDS

HIV Vaccines: New Frontiers in Vaccine Development

Ann Duerr,1

Judith N. Wasserheit,1,2 and

Lawrence Corey1,2

1Clinical Research Division, Fred Hutchinson Cancer Research Center, and 2Department of Medicine, University of Washington, Seattle, Washington

A human immunodeficiency virus (HIV) vaccine is the most promising and feasible strategy to prevent the events during acute infection that simultaneously set the course of the epidemic in the community and the course of the disease for the individual. Because safety concerns limit the use of live, attenuated HIV and inactivated HIV, a variety of alternate approaches is being investigated. Traditional antibody‐mediated approaches using recombinant HIV envelope proteins have shown no efficacy in 2 phase III trials. Current HIV vaccine trials are focusing primarily on cytotoxic T lymphocyte–mediated products that use viral vectors, either alone or as boosts to DNA plasmids that contain viral genes. The most immunogenic of these products appear to be the recombinant adenovirus vector vaccines, 2 of which are now in advanced clinical development.

Received 3 February 2006; accepted 22 April 2006; electronically published 6 July 2006.

Reprints or correspondence: Dr. Ann Duerr, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, LE‐500, Seattle, WA 98109‐1024 ().

Kenneth H. Mayer, Section Editor

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