All Journals > The Journal of Infectious Diseases > 1 September 2006 > CD4+ Cell Nadir and HIV‐Specific Responses

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 September 2006

Volume 194, Number 5
The Journal of Infectious Diseases 2006;194:661–665
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19405-0018$15.00
DOI: 10.1086/505913
BRIEF REPORT

Low CD4+ T Cell Nadir Is an Independent Predictor of Lower HIV‐Specific Immune Responses in Chronically HIV‐1–Infected Subjects Receiving Highly Active Antiretroviral Therapy

M. Atif Siddique,1

Kelly E. Hartman,4

Ella Dragileva,4

Marla Dondero,5

Tebeb Gebretsadik,3

Ayumi Shintani,3

Laurence Peiperl,6

Fred Valentine,7 and

Spyros A. Kalams1,2

1Infectious Diseases Unit, Department of Medicine, and 2Department of Microbiology and Immunology, Vanderbilt University Medical Center, and 3Department of Biostatistics, Vanderbilt University, Nashville, Tennessee; 4Partners AIDS Research Center, Massachusetts General Hospital, Boston; 5AIDS Clinical Trial Group Operations Center, Silver Spring, Maryland; 6University of California–San Francisco, San Francisco; 7New York University Medical Center, New York, New York

The influence of CD4+ T cell nadirs on human immunodeficiency virus (HIV)–specific immune responses in subjects with apparently normal CD4+ T cell counts is not known. We evaluated the frequency of HIV‐1–specific immune responses in a cohort of patients with complete viral suppression (HIV‐1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had a wide range of CD4+ T cell nadirs. We found positive associations between CD4+ T cell nadirs and the magnitude of HIV‐specific CD8+ T cell responses ( ) and of T cell helper responses ( ). These data show the CD4+ T cell nadir to be an independent predictor of HIV‐specific CD4+ and CD8+ T cell responses in HIV‐1–infected subjects with optimal suppression of viremia.

Received 8 December 2005; accepted 29 March 2006; electronically published 28 July 2006.

Reprints or correspondence: Dr. Spyros A. Kalams, 1161 21st Ave., MCN‐A4103, Vanderbilt University Medical Center, Nashville, TN 37232 ().

Cited by

Nicolas Chomont, Mohamed El-Far, Petronela Ancuta, Lydie Trautmann, Francesco A Procopio, Bader Yassine-Diab, Geneviève Boucher, Mohamed-Rachid Boulassel, Georges Ghattas, Jason M Brenchley, Timothy W Schacker, Brenna J Hill, Daniel C Douek, Jean-Pierre Routy, Elias K Haddad, Rafick-Pierre Sékaly. (2009) HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nature Medicine
Online publication date: 21-Jul-2009.
CrossRef
Patricia Price, Sonia Fernandez, Dino B A Tan, Ian R James, Niamh M Keane, Martyn A French. (2009) Nadir CD4 T-Cell Counts Continue to Influence Interferon-γ Responses in HIV Patients Who Began Antiretroviral Treatment With Advanced Immunodeficiency. JAIDS Journal of Acquired Immune Deficiency Syndromes 49:4, 462-464
Online publication date: 1-Jan-2009.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: National Institutes of Health (grants R01 AI39966 to S.A.K., 5U01AI027665 to F.V., program P30 AI 54999 to the Vanderbilt‐Meharry Center for AIDS Research and P30 AI 027742 to the New York University Center for AIDS Research); OPO Foundation, Zurich, Switzerland (support to M.A.S.); Elizabeth Glaser Pediatric AIDS Foundation (Elizabeth Glaser Scientist Award to S.A.K.).

Back to Top
Close Popup