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15 August 2006

Volume 194, Number 4
The Journal of Infectious Diseases 2006;194:474–478
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19404-0009$15.00
DOI: 10.1086/505881
BRIEF REPORT

Persistent Symptomless Human Metapneumovirus Infection in Hematopoietic Stem Cell Transplant Recipients

Maurizia Debiaggi,1

Filippo Canducci,4,5

Michela Sampaolo,4,5

Maria Chiara Marinozzi,4,5

Maurizio Parea,2

Cristina Terulla,2

Anna Amelia Colombo,3

Emilio Paolo Alessandrino,3

Letizia Zenone Bragotti,3

Milena Arghittu,6

Antonio Goglio,7

Roberta Migliavacca,1

Egidio Romero,1,2 and

Massimo Clementi4,5

1Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Università di Pavia, and 2Servizio Analisi Microbiologiche and 3Centro Trapianti di Midollo Osseo, Divisione di Ematologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, 4Laboratorio di Microbiologia e Virologia, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, and 5Università Vita‐Salute San Raffaele, Milano, and 6Azienda Ospedaliera di Melegnano, Presidio di Vizzolo Predabissi, and 7Ospedali Riuniti di Bergamo, Bergamo, Italy

Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection.

Received 24 February 2006; accepted 6 April 2006; electronically published 12 July 2006.

Reprints or correspondence: Dr. Maurizia Debiaggi, Università di Pavia, Dipartimento di Scienze Morfologiche Eidologiche e Cliniche, Sezione di Microbiologia, via Brambilla, 74, 27100, Pavia, Italy ().

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  • Presented in part: annual meeting of the American Society of Hematology, Atlanta, Georgia, 10–13 December 2005 (abstract 106).

    Potential conflicts of interest: none reported.

    Financial support: Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo (grant 08058605); Università di Pavia, Fondo Ateneo di Ricerca 2005.

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