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1 September 2006

Volume 194, Number 5
The Journal of Infectious Diseases 2006;194:666–669
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19405-0019$15.00
DOI: 10.1086/505875
BRIEF REPORT

A Polymorphism That Reduces RANTES Expression Is Associated with Protection from Death in HIV‐Seropositive Ugandans with Advanced Disease

Graham S. Cooke,1

Kerrie Tosh,1

Patricia A. Ramaley,1

Pontiano Kaleebu,4

Joanna Zhuang,1

Jessica S. Nakiyingi,4

Christine Watera,4

Charles F. Gilks,2

Neil French,3,4

James A. G. Whitworth,4 and

Adrian V. S. Hill1

1Wellcome Trust Centre for Human Genetics, Churchill Hospital, University of Oxford, Oxford, 2Imperial College, London, and 3Liverpool School of Tropical Medicine, Liverpool, United Kingdom; 4Medical Research Council Programme on AIDS, Uganda Virus Research Unit, Entebbe, Uganda

We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV‐1) disease progression in an urban population of Uganda. HIV‐positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33–0.83]; ). This report of a non–human leukocyte antigen genetic association with HIV‐1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

Received 10 October 2006; accepted 9 March 2006; electronically published 28 July 2006.

Reprints or correspondence: Dr. Graham Cooke, Wellcome Trust Centre for Human Genetics, Roosevelt Dr., Churchill Hospital, Oxford, United Kingdom, OX3 7BN ().

Cited by

Omer Placide Dossou-Yovo, Isabelle Zaccaria, Malika Benkerrou, Michelle Hauchecorne, Corinne Alberti, Mohamed Chérif Rahimy, Jacques Elion, Claudine Lapoumeroulie. (2009) Effects of RANTES and MBL2 gene polymorphisms in sickle cell disease clinical outcomes: Association of the g.In1.1T>C RANTES variant with protection against infections. American Journal of Hematology 84:6, 378-380
Online publication date: 1-Jul-2009.
CrossRef
Giorgio Sirugo, Branwen J. Hennig, Adebowale A. Adeyemo, Alice Matimba, Melanie J. Newport, Muntaser E. Ibrahim, Kelli K. Ryckman, Alessandra Tacconelli, Renato Mariani-Costantini, Giuseppe Novelli, Himla Soodyall, Charles N. Rotimi, Raj S. Ramesar, Sarah A. Tishkoff, Scott M. Williams. (2008) Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Human Genetics 123:6, 557-598
Online publication date: 1-Aug-2008.
CrossRef
Anurag Rathore, Animesh Chatterjee, P. Sivarama, Naohiko Yamamoto, Pradeep K. Singhal, Tapan N. Dhole. (2008) Association of RANTES −403 G/A, −28 C/G and In1.1 T/C polymorphism with HIV-1 transmission and progression among North Indians. Journal of Medical Virology 80:7, 1133-1141
Online publication date: 1-Aug-2008.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Wellcome Trust (fellowships to G.S.C. and A.V.S.H.); Medical Research Council (grant G9323636).

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